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Full-Text Articles in Life Sciences
An Essential Role For Endocytosis Of Rhodopsin Through Interaction Of Visual Arrestin With The Ap-2 Adaptor, Nicholas R. Orem, Luxi Xia, Patrick J. Dolph
An Essential Role For Endocytosis Of Rhodopsin Through Interaction Of Visual Arrestin With The Ap-2 Adaptor, Nicholas R. Orem, Luxi Xia, Patrick J. Dolph
Dartmouth Scholarship
Previously, we have identified a class of retinal degeneration mutants in Drosophila in which the normally transient interaction between arrestin2 (Arr2) and rhodopsin is stabilized and the complexes are rapidly internalized into the cell body by receptor-mediated endocytosis. The accumulation of protein complexes in the cytoplasm eventually results in photoreceptor cell death. We now show that the endocytic adapter protein AP-2 is essential for rhodopsin endocytosis through an Arr2-AP-2beta interaction, and mutations in Arr2 that disrupt its interaction with the beta subunit of AP-2 prevent endocytosis-induced retinal degeneration. We further demonstrate that if the interaction between Arr2 and AP-2 is …
Pollen Wall Ultrastructure Of Araceae And Lemnaceae In Relation To Molecular Classifications, Michael Hesse
Pollen Wall Ultrastructure Of Araceae And Lemnaceae In Relation To Molecular Classifications, Michael Hesse
Aliso: A Journal of Systematic and Floristic Botany
A comparative ultrastructural study of Araceae pollen walls was conducted for the first time. The results are based mainly on investigations by transmission electron microscopy of 101 species in 70 genera (out of a total of 105 genera), while pollen of 83 genera with 219 species were studied by scanning electron microscopy, generally without acetolysis. Special attention was given to Lemnaceae (including Limnobiophyllum) considered to be closely related to Araceae (especially to Pistia). The ultrastructural pollen wall characters are mostly in accordance with and strongly support the morphological classifications and the arrangement of genera within recent molecular trees. …