Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Institution
- Publication
- Publication Type
Articles 1 - 5 of 5
Full-Text Articles in Life Sciences
The Role Of Drosophila Odorant Receptors In Odor Coding, Elane Fishilevich
The Role Of Drosophila Odorant Receptors In Odor Coding, Elane Fishilevich
Student Theses and Dissertations
Drosophila melanogaster is a powerful genetic model organism, and a promising model system in olfaction. At the onset of my thesis research, the expression patterns of fly’s 62 odorant receptors (ORs) were largely unknown. I set out to understand the rules of connectivity of olfactory sensory neurons and the resulting properties of olfactory circuit. Consequently, we assembled maps of the olfactory neuron projections in the fly brain and characterized the contribution of several ORs to olfactory-guided behavior. We compiled near-complete maps of OR-specific neuronal projections to the antennal lobe glomeruli of adult and larval fly brains. We analyzed expression profiles …
Mapping And Characterization Of 18-5 And 12-5, Genes Which Potentially Link The Rhoa Signaling Pathway To The Ecdysone Response, Samuel Fox
Electronic Theses and Dissertations
Systemic steroid hormone and intracellular signaling pathways are known to act cooperatively during the development of vertebrate and invertebrate epithelia. However, the mechanism of this interaction is poorly understood. Morphogenesis of Drosophila leg imaginal disc epithelia is regulated both by the steroid hormone 20-hydroxyecdysone (ecdysone) and the RhoA GTPase signaling pathway. Recent evidence suggests that these pathways act cooperatively to control imaginal disc morphogenesis. Thus, leg imaginal disc morphogenesis is an excellent system in which to study the interaction of steroid hormone and intracellular signaling pathways. We have identified mutations in three genes, 12-5, 18-5, and 31-6, with roles in …
Notopleural Mutations Enhance Defects In Imaginal Disc Epithelial Morphogenesis And Macrochete Elongation Associated With Mutations In The Stubble-Stubbloid Locus, Robert Ruggiero
Electronic Theses and Dissertations
The Stubble-stubbloid locus encodes a transmembrane serine protease (Stubble) necessary for the proper formation of sensory bristles, and the morphogenesis of leg and wing epithelia. Genetic and cell biological analysis indicate a role for Stubble in actin cytoskeletal dynamics and cell shape changes in developing epithelia and bristles. Previously reported genetic interactions between Stubble and the Rho1 signaling pathway suggest Stubble influences actin cytoskeleton dynamics in developing imaginal discs through interactions with the Rho1 pathway. This work will discuss a genetic screen conducted to further investigate the role of Stubble in bristle and imaginal disc morphogenesis. From 50,000 EMS-mutagenized chromosomes …
Testing The Randomness Of The Samples Of Body Size In A Replicated Design In Drosophila Melanogaster Populations From The Eastern Mediterranean, Ergi̇ Deni̇z Özsoy, Ali̇ Ni̇hat Bozcuk
Testing The Randomness Of The Samples Of Body Size In A Replicated Design In Drosophila Melanogaster Populations From The Eastern Mediterranean, Ergi̇ Deni̇z Özsoy, Ali̇ Ni̇hat Bozcuk
Turkish Journal of Zoology
Strong body size correlates, wing and thorax lengths, of Drosophila melanogaster populations from the Eastern Mediterranean were measured and tested for the presence of autocorrelation, i.e. nonrandom alternation of individual measurements within a sample. The experimental design was a laboratory setup aiming at overall homogeneity in fly culture conditions, which was achieved. A t-test, first proposed by Von Neumann, was performed for the autocorrelation analysis in each population. No significant autocorrelation was detectable, indicating very low bias in the experimental design for nonrandom picking of individuals for measurements. The test is suggested for routine use in studies before any inference …
The Developmental And Molecular Basis Of Allometry In Drosophila, Alexander W. Shingleton, Jennifer A. Brisson, David L. Stern
The Developmental And Molecular Basis Of Allometry In Drosophila, Alexander W. Shingleton, Jennifer A. Brisson, David L. Stern
School of Biological Sciences: Faculty Publications
Allometry is the scaling relationship between the size of an organism and the size of its constituent parts. Despite its obvious developmental and evolutionary importance, very little is known of the mechanisms that regulate allometries. Here, we look at one particular type of allometry—that created by rearing Drosophila under different nutritional conditions. Drosophila larvae that are fed increasingly suboptimal diets eclose into increasingly small adults with increasingly small body parts. Surprisingly, however, the male genitals remain approximately the same size under a range of nutritional conditions. The genitals therefore maintain a different allometric relationship with the body than other structures. …