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Manganese Toxicity In Mice: Evaluation Of Neruochemical And Immunologial Alteration, Benjamart Srisuchart

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Neurochemical and immunological effects of manganese chloride (MnCl₂) were evaluated using young male CD-1 mice as the animal model. Intraperitoneal (i.p.) injection of MnCl₂ (1, 3 and 10 mg/kg) daily for 4 weeks did not produce mortality or overt signs of toxicity in any of the treated animals. Manganese treatment increased the thymidine uptake of cultured splenic cells and the selective lymphoproliferative response to T-cell mitogens, phytohaemagglutinin and concanavalin A, in all the treated groups. No difference in the response to B-cell mitogen, lipopolysaccharide was observed. A dose of 10 mg/kg MnCl₂ increased the mixed lymphocyte …