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Monoclonal Antibodies Reveal The Structural Basis Of Antibody Diversity, Jean-Luc Teillaud, Catherine Desaymard, Angela Giusti, Barbara Haseltine, Roberta Pollock, Dale Yelton, Donald Zach, Matthew Scharff
Monoclonal Antibodies Reveal The Structural Basis Of Antibody Diversity, Jean-Luc Teillaud, Catherine Desaymard, Angela Giusti, Barbara Haseltine, Roberta Pollock, Dale Yelton, Donald Zach, Matthew Scharff
Roberta Pollock
Hybridoma technology has made it possible to introduce into continuous culture normal antibody-forming cells and to obtain large amounts of the immunoglobulin produced by each of these cells. Examination of the structure of a number of monoclonal antibodies that react with a single antigen has provided new information on the structural basis of the specificity and affinity of antibodies. Comparisons of families of monoclonal antibodies derived from a single germ line gene revealed the importance of somatic mutation in generating antibody diversity. Monoclonal antibodies that react with variable regions of other monoclonals allow the further dissection and modulation of the …