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Modification Of A Rapidly Transported Protein In Regenerating Nerve, Bruce Tedeschi, David L. Wilson
Modification Of A Rapidly Transported Protein In Regenerating Nerve, Bruce Tedeschi, David L. Wilson
Biology Articles and Papers
From 1 to 28 days after frog sciatic nerve damage, dorsal root ganglia were incubated with [35S] methionine, and the labeled, rapidly transported proteins at various points along the nerve were analyzed on two-dimensional gels. The results show a dramatic increase in the labeling of a protein, which we have designated as A25, only after the arrival of the rapidly transported proteins at regenerating nerve tips. This effect is first seen 3 to 5 days after injury. On gels from regenerating nerves, A25 appears as a series of intense spots with an apparent molecular weight of 70,000. A25 is retrogradely …