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Full-Text Articles in Life Sciences
Factors Affecting The Antibacterial Activity Of Cefiderocol On Klebsiella Pneumoniae With Diverse Characteristics, Lana Jamal Rashed Daoud
Factors Affecting The Antibacterial Activity Of Cefiderocol On Klebsiella Pneumoniae With Diverse Characteristics, Lana Jamal Rashed Daoud
Theses
Antimicrobial resistance (AMR) is a growing serious threat that poses a burden on the healthcare system. Spread of AMR bacteria limits treatment options; thus, new antimicrobial agents are required. Cefiderocol (CFDC) is a novel siderophore cephalosporin, approved by the FDA in 2019 for use in treating infections caused by multi-drug resistant (MDR) pathogens; but it is not yet in clinical use in the UAE. CFDC is equipped with stabilizers against β-lactamases as well as a siderophore side chain that allows it to penetrate the outer membrane of bacteria through the iron uptake pathways. The aim of this study is to …
Elucidation Of Novel And Established Campylobacter Species With Clinical And Agricultural Significance Through Phenotypic, Genotypic, And Taxonomic Investigation, Caoimhe Lynch
Theses
Campylobacter spp. are well-established human, veterinary and economic pathogens, with a broad host range spanning from terrestrial and marine mammalian, avian and reptilian hosts. The scope of the study includes novel and notorious species within the genus, with reference to zoonotic agents Campylobacter jejuni and Campylobacter coli - the leading cause of human bacterial gastroenteritis in the EU and Ireland, Campylobacter fetus that represents the most common campylobacter causing bacteraemia and two novel species isolated from pigs not described in the literature previously. C. jejuni and C. coli isolates (n = 350) recovered from broiler caecal and neck skin samples, …
Investigation Of The Natural Bacteriocin Nisin And Bioengineered Nisin Derivatives For The Prevention And Control Fo Staphylococcus Biofilms On Medical Device Materials, Leanne Kearney
Theses
Antimicrobial resistance has evolved into being one the major threats facing clinical environments worldwide. It has led to the deerease in effective prevention and treatment of pathogenic bacteria. One such bacterium is Staphylococcus epidermidis. Once considered a relatively harmless and commensal baeterium, it has recently evolved into being one the leading eauses of nosocomial infections. S. epidermidis has proven hamiful due to its ability to fonn detrimental biofilms. Biofilms are structured eonsortia of bacteria embedded in a self-produced polymer matrix that allows adherence to biotic or abiotic surfaces. These biofilms have played a leading role in healthcare-acquired infections with particular …