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Androgen Receptor And The Testes Influence Hypertension In A Hybrid Rat Model, Daniel Ely, Ron Salisbury, Disha Hadi, Monte E. Turner, Mark L. Johnson
Androgen Receptor And The Testes Influence Hypertension In A Hybrid Rat Model, Daniel Ely, Ron Salisbury, Disha Hadi, Monte E. Turner, Mark L. Johnson
Biology Faculty Research
The objective of this study was to determine if males with a deficient androgen receptor would develop hypertension when crossed with a hypertensive parent. Female King-Holtzman rats (n = 15), heterozygous for the testicular feminization (Tfm) gene, were crossed with male spontaneously hypertensive rats (SHR), and blood pressure was measured weekly from 5-14 weeks in the F1 hybrid males. Approximately 50% of the F1 hybrid males were Tfm males and androgen receptor-deficient, and 50% were normal. Blood pressure in the parent King-Holtzman males, Tfms, and female rats was also followed for the same time period. The F1 normal male hybrids …