Life Sciences Commons^™

Barbara Sanford Oral History, Barbara Sanford

Oral History Collection

Susan Mehrtens' Note:

Barbara Sanford's interview echoes most of what I have heard from many of the staff regarding the Lab's mission and goals. The Lab's ideal size, geographical location--with its pluses and minuses--and the environment in which to do science in the current period--all find echoes on other tapes. There is little of candor, consequence or calculation here. Sanford clearly recognizes the stressful nature of scientific life in these times of federal cutbacks, and, as well, the frustrations of directing a laboratory whose size, complexity and needs preclude personal scientific work by the Director. In the face of such …

Donald Bailey Oral History, Donald Bailey

Oral History Collection

Susan Metrhens' Note:

Regarded by many of his peers at Jax as one of the most intuitive, prescient and creative scientists at the Lab, Bailey was a very reflective narrator. While he provides one anecdote of c.c. Little1s sartorial habits, this tape is largely devoid of anecdotal material, and is more a reminiscence by a scientist who was at Jax in the early '50's, who left and returned in 1967. I tried, through a variety of questions, to probe the synergy between Bailey and the Lab, the degree to which his prescience and creativity might be due to the freedom …

Priscilla "Skippy" Lane Oral History, Skippy Lane

Oral History Collection

Susan Mehrtens' Note:

We have in this tape the recollections of one of the most prolific authors in the field of mouse mutants, an indefatigable co-worker of Margaret Dickey, Margaret Green and currently, Muriel Davison. Full of scientific terms, this tape reveals clearly Lane's thorough absorption in the field to which she has devoted nearly the last forty years of her life. Toward the end of this tape, Lane alludes to Earl Green's sexist attitude, which other women have also mentioned to me on and off tape. Lane also waxes eloquently here about her efforts to establish a hiera'rchy within …

Prevalence Of Sensitivity To Sulfiting Agents In Asthmatic Patients, Robert K. Bush, Steve L. Taylor, Karen Holden, Julie A. Nordlee, William S. Busse

Department of Food Science and Technology: Faculty Publications

Ingestion of sulfiting agents can induce wheezing in some asthmatic patients. However, neither the prevalence of sulfite sensitivity nor the clinical characteristics of the affected asthmatic population are known. In a prospective single-blind screening study, 120 non-steroid-dependent and 83 steroid-dependent asthmatic patients underwent challenge with oral capsules of potassium metabisulfite. Five non-steroid-dependent and 16 steroid-dependent asthmatic patients experienced a greater than 20 percent reduction in their one-second forced expiratory volume within 30 minutes following the oral challenge. Twelve of these sulfite reactors were rechallenged with metabisulfite capsules in a double-blind protocol. Under these conditions, only three of seven steroid-dependent patients …

The Case For The Use Of Animals In Biomedical Research, Carl Cohen

Morality and Ethics of Animal Experimentation Collection

No abstract provided.

Genetic Characterization Of Human C-Rel Sequences, Elise Brownell, Stephen J. O'Brien, William Nash, Nancy Rice

Biology Faculty Articles

We isolated and sequenced a human genomic-DNA segment that is homologous to a portion of v-rel, the transforming gene of reticuloendotheliosis virus (strain T). We also localized the human rel sequences to human chromosome 2 by screening a panel of rodent x human somatic-cell hybrids with the newly described human rel segment.

Thomas Roderick Oral History, Thomas Roderick

Oral History Collection

Susan Metrhens' Note:

Roderick has been a scientist at Jax for thirty years, working in no other place. He was hired just as Earl Green replaced C.C. Little and Roderick worked with and for Green for some dozen years before moving into his own lab, on his own grants. Roderick is both perceptive and analytical and this tape is valuable for his willingness to reflect on trends and personalities. He also has a philosopher's willingness to consider the values that drive the lab. Roderick was forthcoming with anecdotes, including a most telling one of Rich Prehn showing the courage of …

Alternatives Sought To Save Lab Animals, Jim Detjen

Popular Press Items

No abstract provided.

Dale Foley Oral History, Dale Foley

Oral History Collection

Susan Mehrtens' Note:

Dale Foley was the administrative "right arm" of both Little and Green, and, as such, was in a position to comment on the Lab's financial and administrative activities from the perspective of a key participant. As we began, he brought out several pages of notes, which formed the basis of the monologue that followed. To my surprise, his tape consists almost totally of accounts of the acquisition of property and building of the major Jax buildings. Aside from references to several valued Jax volunteers--several of them wealthy Trustees--Foley stuck to the physical plant in his interview. Intuitively, …

Willys Silver Oral History, Willys Silver

Oral History Collection

Susan Mehrtens' Note:

Both Will Silvers and I enjoyed this interview, despite the hot, stuffy room we had at the Lab (in which the wind seemed to howl incessantly, through some pinhole crack somewhere, as is audible on tape). Initially at a loss as to what to expect in this process, Silvers soon moved into high gear and his verve and excitement are obvious. Perhaps more than anyone else included in this project, Silvers spans the constituencies ~f the Lab, as summer student, employee, summer investigator, and finally BSO member. He is forthcoming about all these roles, giving us a …

James Ebert Oral History, James Ebert

Oral History Collection

No abstract provided.

The Incidence Of Cryptosporidial Infections In Nebraska Dairy Calves, Douglas Lee Varner

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

Within the last decade a new etiologic agent has been identified as a possible cause of diarrhea in humans and domestic animals—that being the protozoan parasite Cryptosporidium. The purpose of this study was to determine the incidence and distribution of Cryptosporidium in the state of Nebraska, to determine if Cryptosporidium occurs more frequently in association with other enteropathogens and to determine about the relation of scouring in the calves to infection with Cryptosporidium. A total of 620 fecal samples from 334 dairy calves from 71 herds in Nebraska were examined for cyptosporidial oocysts using the Sheather’s sugar flotation …

Absence Of A Structural Basis For Intracellular Recognition And Differential Localization Of Nuclear And Plasma Membrane-Associated Forms Of Simian Virus 40 Large Tumor Antigen., Donald L. Jarvis, Charles N. Cole, Janet S. Butel

Dartmouth Scholarship

The simian virus 40 large tumor antigen (T-ag) is found in both the nuclei (nT-ag) and plasma membranes (mT-ag) of simian virus 40-infected or -transformed cells. It is not known how newly synthesized T-ag molecules are recognized, sorted, and transported to their ultimate subcellular destinations. One possibility is that these events depend upon structural differences between nT-ag and mT-ag. To test this possibility, we compared the structures of nT-ag and mT-ag from simian virus 40-infected cells. No differences between the two forms of T-ag were detected by migration in polyacrylamide gels, by Staphylococcus aureus V8 partial proteolytic mapping of methionine- …

American Philosophical Society Finding Aid For Jax Oral History, Aps Phila, Pa

Personal Papers Collection

In 1929, the geneticist C. C. Little founded the Roscoe B. Jackson Memorial Laboratory in Bar Harbor, Maine, a major center for the study of mammalian genetics, cancer, and related areas in basic biomedical research. An independent institution, the Lab has maintained a consistent scientific reputation both as a supplier of inbred strains of mice for genetic and biomedical research and for the scientific achievements of its researchers. Conducted by Susan Mehrtens in 1986, the Oral History Collection includes transcripts of extensive interviews with fifty scientists, administrators, and staff members of the Jackson Laboratory. At greater or lesser length depending …

Barley Foliar Diseases And Blackspot Of Field Peas., T. N. Kahn, M. Judges, K. Embry

Experimental Summaries - Plant Research

Barley foliar diseases, Blackspot of field peas. 86BA15, 86C13, 86BA12, 86MT10, 86M10, 86BA13, 86BA14, 86M029-31, 86N079, 86GE27, 86M029, 86GE28, 86TS28, 86WH12, 86C4, 86C11, 86C5, 86C6, 86C12, 86C7, 86KA56, 86M45, 86BA15, 86MT13, 86C13, 86BA16, 86MD35, 86MT14, 86MD36.

Fungicide Testing, M. J. Barbetti

Experimental Summaries - Plant Research

Fungicidal control of Phoma blackstem disease in medic, 86 KA 11. Medic cultivar susceptibility to Phoma blackstem disease, 85 KA 56. Role of Phoma seed infection in medic, 85 KA 57. Effect of soil pasteurization on damage caused by six fungal root pathogens, 86 PE 53. Susceptibility of 18 sub-clover cultivars to isolates of the clover scorch fungus, Kabatiella caulivora, 86 PE 54. Effect of plant age or growth stage of subterranean clover on susceptibility to infection by the clover scorch fungus, Kabatiella caulivora, 86 PE 55. Susceptibility of rapeseed lines to blackleg crown canker, 86 MT 1, 86 MT …

Foliar Wheat Diseases And Cereal Smuts., R. Loughman, A. E. Twigg

Experimental Summaries - Plant Research

Chemical control of leaf spots of wheat, 86BA41, 86MT49. Semi-natural inoculum for plant breeders plots, 86MD2. Chemical control of soil-borne flag smut, 86ME73, 86M032. Chemical control of barley loose smut, 86AL50, 86KA59, 86MT47. Chemical control of loose smut in barley with different levels of seed infections, 86MT48. Disease characterisation of cereal variety trial stage 4 sites.

Lupin Root Rot, Lupin Hypocotyl Rot, Rhizoctonia Coleoptile Rot Of Wheat, Rhizoctonia Root Rots In Long Term Wheat-Pasture Rotation Trials., M. Sweetingham

Experimental Summaries - Plant Research

Lupin Root Rot: 86Cl4, 86WH15, 86ME85, 86LG63, 85C63, 86WH14. Lupin Hypocotyl rot, 86BA49, 86BA21. Rhizoctonia coleoptile rot of wheat, 86BA19, 86BA20 Rhizoctonia root rots in long term wheat-pasture rotation trials.

Fruit Diseases., P. Mcr Wood

Experimental Summaries - Plant Research

Apple Powdery Mildew, 86BY42. Peach Leaf Curl, 86MN6. Pear Scab, 86MN7.

The Significance Of Alternative Techniques In Biomedical Research: An Analysis Of Nobel Prize Awards, Martin Stephens

Experimentation Collection

No abstract provided.

The Case Against The Use Of Animals In Science, Donald J. Barnes

Experimentation Collection

As a scientist long committed to the understanding, prediction, and control of biological, physiological, and behavioral events, I have no objection to the animal as a legitimate focus of science. As a parent, a son, a sibling, and the proud recipient of unconditional positive regard from a few special people, I am vitally interested in matters of health and in the most ethically efficient use of available resources. As a member of a species which has evolved sufficiently to allow the relatively broad perspective of a "web of life" and at least a rudimentary concept of altruism, I have laboriously …

The Case For The Use Of Animals In Science, James A. Will

Experimentation Collection

Animals are now used extensively in research and teaching, and the appropriateness of their use appears to be questioned. Some people believe that we are in a new era where the animal activists have become much more influential, and that the antagonism between the scientists and these groups is worse than it ever has been. This does not appear to be the case. The preeminence of various influences seems rather cyclic, even perhaps influenced by such things as economic conditions or wars. At present, the question is often asked, "Should we continue to use animals in science?" The real question …

Socialized Vs. Unsocialized Wolves (Canis Lupus) In Experimental Research, Harry Frank, Linda M. Hasselbach, Dawn M. Littleton

Experimentation Collection

In the experimental setting human contact is both more frequent and more intimate than in observational research, and the issue therefore assumes even greater importance. The present paper discusses two experimental studies of wolf information processing, one of which was conducted with unsocialized animals and one of which was conducted with socialized animals, and examines the both the management and methodological consequences of these approaches.

Wildlife And Nature Liberation, Michael W. Fox

Conservation Collection

Humane ethics--animal welfare--and animal rights are not incompatible with ecologically sound wildlife stewardship. They are an integral part of it, from treating wildlife for necessary research purposes humanely, to finding humane ways to control the populations of species that are out of balance and thus threatening the viability of other species and the diversity and integrity of the ecosystem. That mistakes may be made in stewardshipmanagement policies is inevitable. It is, for instance, difficult to know if the sudden abundance of one or more species and the dwindling of others is part of the natural process of succession and should …

Wildlife Conservation And Animal Rights: Are They Compatible?, Michael Hutchins, Christen Wemmer

Conservation Collection

The purpose of this paper is to explore the philosophical tenets of the animal rights/humane ethic as they relate to the environmental ethic and, more specifically, as they relate to wildlife management and conservation. The two ethics will be compared in an effort to identify potential sources of conflict. Recent criticisms of the animal rights ethic, most notably by Fox (1978, 1979), Rodman (1977), Callicott (1980), Gunn (1980), and Hutchins et al. (1982) have identified several major discrepancies. The implications of these differences will be discussed.

Formation Of Influenza Virus Particles Lacking Hemagglutinin On The Viral Envelope, Asit K. Pattnaik, Donald J. Brown, Debi P. Nayak

School of Veterinary and Biomedical Sciences: Faculty Publications

We investigated the intraceUular block in the transport of hemagglutinin (HA) and the role of HA in virus particle formation by using temperature-sensitive (Is) mutants (1s134 and 1s61S) of inOuenza virus AlWSN/33. We found that at the nonpermissive temperature (39.5°C), the exit of ts HA from the rough endoplasmic reticulum to the Golgi complex was blocked and that no additional block was apparent in either the exit from the Golgi complex or post-Golgi complex transport. When MDBK ceUs were infected with these mutant viruses, they produced noninfectious virus particles at 39.5°C. The efficiency of particle formation at 39.5°C was essentiaUy …

The Case For The Use Of Animals In Medicine, Gary F. Merrill

Experimentation Collection

The use of animals in medical research and teaching, and the public concern this has generated is not a new issue (Visscher 1969). Ever since scientists began using animals to investigate the function of the body in health and disease, there have been those who opposed their work (Fishman and Richards 1982). Whether this controversy is cyclic is not known, but most concerned biomedical investigators agree that the opposition is here to stay. The author shares this opinion, and thus maintains that it is in the best interest of all parties to be properly educated on the issues. Only through …

Ua35/11 Student Honors Research Bulletin, Wku Honors Program

WKU Archives Records

The WKU Student Honors Research Bulletin is dedicated to scholarly involvement and student research. These papers are representative of work done by students from throughout the university.

• Padilla, Anne. First and Second Language Acquisition: A Comparison
• Scott, Angela. Salted and Unsalted Snacks: Taste Preferences of Second Grade Students in a Rural Area School
• Fuqua, Nancy. Acceptance by High School Students of Muffins Containing Supplemental Soy Polysaccharides
• Mans, Glee. Preference Levels of High School Freshmen for Four Cheese Food Products
• Denney, Pam. Consumer Acceptance of UHT Choclate Lowfat Milk
• Harris, Carla. Jacques-Louis David: Raphael of the Sansculottes
• Vaughn, James. Corporate Reorganization …