Life Sciences Commons^™

Artificial Intelligence And Machine Learning Based Techniques In Analyzing The Covid-19 Gene Expression Data: A Review, Santhosh K, Ajitha S, Sushma Pradeep, Kuralyanapalya Putta Honnappa Suresh, Sharanagouda S Patil, Shiva Prasad Kollur, Chandan Shivmallu

International Journal of Health and Allied Sciences

The novel Coronavirus associated with respiratory illness has become a new threat to human health as it is spreading very rapidly among the human population. Scientists and healthcare specialists throughout the world are still looking for a breakthrough technology to help combat the Covid-19 outbreak, despite the recent worldwide urgency. The use of Machine Learning (ML) and Artificial Intelligence (AI) in earlier epidemics has encouraged researchers by providing a fresh approach to combating the latest Coronavirus pandemic. This paper aims to comprehensively review the role of AI and ML for analysis of gene expressed data of COVID-19

Wellness Review 2022, Part 1, Martin Huecker, Brian A. Ferguson, Jacob Shreffler

Journal of Wellness

Introduction: This article represents the first of a two-part assessment of 2022 literature addressing wellness in healthcare professionals published from January 1, 2022 to June 30, 2022.

Methods: Three editors conducted a similar keyword search in Pubmed, also adding manually curated articles. Focusing chiefly on clinical trials and other prospective research, we settled on a final 25 significant papers focusing on wellness in medical professionals to include in this review.

Literature Review: Recent literature into HCW wellness continues to describe burnout factors and COVID-19 impact, but includes more resilience-targeting interventions and systematic reviews of trials seeking bolstering of well-being. Subsections …

Wastewater-Informed Public Health Intervention Playbook

Sustain Magazine

As the SARS-CoV-2 pandemic quickly spread from country to country and continent to continent in 2020, governments and scientists needed a way to track COVID-19 through populations in order to position public health interventions in the most impactful locations. Having a decision-based risk framework may help to guide policy creation that could minimize or prevent possible outbreaks and surges of infection within communities. The University of Louisville in partnership with Louisville’s Department of Public Health and Wellness tested this strategy in 2021 and 2022. This Wastewater-Informed Public Health Intervention Playbook describes the decisions and actions of that academic and public …

Kl-6 In Ards And Covid-19 Patients, Ornella Piazza, Giuliana Scarpati, Giovanni Boccia, Massimo Boffardi, Pasquale Pagliano

Translational Medicine @ UniSa

The Acute Respiratory Distress Syndrome (ARDS) is a common, devastating clinical pattern characterized by life-threatening respiratory failure. In ARDS there is an uncontrolled inflammatory response that results in alveolar damage, with the exudation of protein-rich pulmonary-edema fluid in the alveolar space. Although severe COVID-19 lung failure (CARDS) often meets diagnostic criteria of traditional ARDS, additional features have been reported, such as delayed onset, binary pulmonary compliant states, and hypercoagulable profile. Increased levels of Krebs von den Lungen 6 (KL-6, also known as MUC1) have been reported in both ARDS and CARDS. KL-6 is a transmembrane protein expressed on the apical …

Development Of Tlc Fingerprinting Profile Of Shadanga Paniya – An Ayurvedic Formulation To Treat Symptoms Of Covid-19, Mehta D. Mehul, Kunal M. Gohil, Krunal A. Doshi

International Journal of Health and Allied Sciences

BACKGROUND: Shadanga Paniya is a compound Ayurvedic formulation that contains six ingredients. Ayurvedic Physicians have been using Shadanga Paniya to treat fever for ages. Symptoms of COVID-19 are also being treated by Shadanga Paniya. However, the Shadanga Paniya has not reported standardisation.

AIMS: To prepare Shadanga Paniya as per the standard classical protocol. To carry out qualitative tests, standardisation and TLC profile development for Shadanga Paniya.

MATERIALS AND METHODS: All the ingredients of Shadanga Paniya wiz. Nagarmotha, Pittapapada, Khasa, Lal Chandana, Sugandhbala and Sunthi were taken in equal amounts. All these ingredients are heated over mild heat with water. The …

Edible Mushrooms: An Emerging Therapeutic Of Diabetes, Nilanjan Chakraborty, Anuron Banerjee, Sudeshna Nandi, Swagata Sarkar, Krishnendu Acharya

The Thai Journal of Pharmaceutical Sciences

Diabetes is the third most customary non-infectious disease occurring worldwide and leads to untimely disability and mortality. This metabolic disorder is characterized by impaired insulin secretions and high blood glucose levels. Among others, type 2 diabetes is the most common. Various chemical and biochemical hypoglycemic drugs are utilized to control and treat hyperglycemia but required further interventions to reduce their toxicity and side effects on the users. Edible mushrooms have been employed from ancient times to heal many diseases as it composed of anti-oxidant, alkaloids, fibers, triterpenoids, and other phytochemicals. The bioactive secondary metabolites of mushrooms can improve insulin resistance …

Sustainable Development Goals: A Business Opportunity, Mariia Nezhyva, Viktoriia Mysiuk

Journal of Environmental Science and Sustainable Development

Article deals with the economic importance of sustainable development its component and their impact on the economy and business. The preconditions, theoretical, and applied principles of sustainability are investigated. The article substantiates the need to determine the priorities of innovation for sustainable development. The measures and goals to be taken to implement the innovative component of sustainable development are proposed to get virality of business opportunity. Economic changes and environmental pressures are sparking new levels of global concern, shifting consumers' values, preferences, and behavior. In response, businesses should consider the idea of a purpose beyond economic profit to design products …

The Adaptation Of Export-Scale Urban Farmers Amid The Covid-19 Pandemic In Bandung Metropolitan, Kinanti Indah Safitri, Oekan Soekotjo Abdoellah, Budhi Gunawan, Parikesit -, Yusep Suparman, Akhmad Zainal Mubarak, Margareth Pardede

The Qualitative Report

These days, urban agriculture is more than a hobby. It has expanded into a local commercial business, even to an export scale. However, urban farmers who have commercialized their products must adapt to the COVID-19 pandemic situation, which has impacted many aspects of global life. This research used a mixed-method approach. We collected quantitative data from 107 respondents on the household commercialization index, income level, and education level of export-scale-urban farmers in the Bandung metropolitan area, West Java, Indonesia. We also used qualitative data to determine how farmers were adapting to difficult situations due to the COVID-19 pandemic. This information …

Perceptions And Readiness Of Foodservice Establishments At The Onset Of The Covid-19 Pandemic In Metro Manila And Region Iv-A, Philippines, Von Ryan M. Ebron, Irma U. Danao, Marie Faye R. Nguyen- Orca, Anna Teresa O. Orillo, Joyce P. Parco

Journal of Economics, Management and Agricultural Development

The study evaluated the perceptions and readiness of food business operators about COVID-19 through an online survey with respondents from Metro Manila and Region IV-A. Generally, they are knowledgeable about COVID-19 and its transmission, as reflected in their scores. The same is true about their attitude towards “new normal” practices. Years of operation, asset size, and continued operations and delivery services showed significant positive correlation with attitude scores. The resilience of some food business operators may be attributed to having more resources that enabled them to carry the added costs of what the new normal foodservice practices entailed. New normal …

Orally Delivered Perilla (Perilla Frutescens) Leaf Extract Effectively Inhibits Sars-Cov-2 Infection In A Syrian Hamster Model, Yuan-Fan Chin, Wen-Fan Tang, Yu-Hsiu Chang, Tein-Yao Chang, Wen-Chin Lin, Chia-Yi Lin, Chuen-Mi Yang, Hsueh-Ling Wu, Ping-Cheng Li, Jun-Ren Sun, Shu-Chen Hsu, Chia-Ying Lee, Hsuan-Ying Lu, Jia-Yu Chang, Jia-Rong Jheng, Cheng Cheung Chen, Jyh-Hwa Kau, Chih-Heng Huang, Cheng-Hsun Chiu, Yi-Jen Hung, Hui-Ping Tsai, Jim-Tong Horng

Journal of Food and Drug Analysis

On analyzing the results of cell-based assays, we have previously shown that perilla (Perilla frutescens) leaf extract (PLE), a food supplement and orally deliverable traditional Chinese medicine approved by the Taiwan Food and Drug Administration, effectively inhibits SARS-CoV-2 by directly targeting virions. PLE was also found to modulate virus-induced cytokine expression levels. In this study, we explored the anti-SARS-CoV-2 activity of PLE in a hamster model by examining viral loads and virus-induced immunopathology in lung tissues. Experimental animals were intranasally challenged with different SARS-CoV-2 doses. Jugular blood samples and lung tissue specimens were obtained in the acute disease stage (3−4 …

The Risk And Prognosis Of Covid-19 Infection In Cancer Patients: A Systematic Review And Meta-Analysis, Ghada M. Elgohary, Shahrukh Hashmi, Jan Styczynski, Mohamed A. Kharfan-Dabaja, Rehab M. Alblooshi, Rafael De La Camara, Sherif Mohmed, Alfadel Alshaibani, Simone Cesaro, Nashwa Abd El-Aziz, Reem Almaghrabi, Usama Gergis, Navneet S. Majhail, Roy F. Chemaly, Mahmoud Aljurf, Riad El Fakih

Hematology/Oncology and Stem Cell Therapy

Numerous studies have been published regarding outcomes of cancer patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus causing the coronavirus disease 2019 (COVID-19) infection. However, most of these are single-center studies with a limited number of patients. To better assess the outcomes of this new infection in this subgroup of susceptible patients, we performed a systematic review and meta-analysis to evaluate the impact of COVID-19 infection on cancer patients. We performed a literature search using PubMed, Web of Science, and Scopus for studies that reported the risk of infection and complications of COVID-19 in cancer patients …

The Relationship Between Perceived Stress And Disordered Eating In Undergraduate Students During The Covid-19 Pandemic, Caroline G. Martin

Gettysburg College Headquarters

The COVID-19 pandemic has affected and imposed challenges on nearly everyone, including college students. Despite their already stressful situations, previous research has demonstrated increased stress levels among college students during the COVID-19 pandemic. Additionally, research has also shown an increase in disordered eating for college students during the pandemic. However, few studies have investigated the relationship between both perceived stress and disordered eating during the COVID-19 pandemic. Therefore, the present study used a correlational design to investigate a potential association between perceived stress and disordered eating among undergraduate college students during the COVID-19 pandemic. By administering the EAT-26, the CSSEC, …

Academic Resilience Of Athletic Training Students During Covid-19 Pandemic, Brandon J. Gallimore, Laura Harris, Janet E. Simon

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE
(1) To describe resilience in athletic training students enrolled in professional coursework during the spring 2020 semester, and (2) to determine the association between resilience and academic performance during the spring 2020 semester.

MAIN OUTCOME MEASURES
Descriptive statistics for GPA were calculated for Fall 2019, Spring 2020, cumulative Fall 2019, cumulative Spring 2020 (ie., current), change in cumulative GPA, and ARS-30 total score. The primary analysis was a Pearson correlation between change in cumulative GPA and ARS-30 total score. A secondary analysis was conducted to evaluate change in cumulative Fall 2019 and Spring 2020 GPA with a paired t-test. …

The Racial Divide: A Follow Up Study On Racial Disparity Amongst Covid-19 Survivors In An Urban Community, Christopher Millet, Emily Racoosin, Spandana Narvaneni, George Horani, Sherif Roman, Alisa Farokhian, Arslan Chaudhry, Sohail Chaudhry, Yezin Shamoon, Humberto Jimenez, Patrick Michael, Jin Suh

Journal of Community Hospital Internal Medicine Perspectives

Background Studies have shown that COVID-19 has had a disproportionate effect on minority groups in both the clinical and social settings in America. We conducted a follow up study on patients previously diagnosed with COVID-19 one year ago in an urban community in New Jersey. The purpose of the study was to evaluate the socioeconomic impact of COVID-19 as well as assess for receptiveness towards COVID-19 vaccination amongst various ethnic groups.

Methods This was a prospective cohort study consisting of patients who had recovered from COVID-19 one year prior. The patients included in the study had a confirmed COVID-19 diagnosis …

Covid-19 In Lebanon: Demographics And Distribution, Mahdi Fadlallah, Fadi Hobeiche, Marie Therese Jamal, Elie Salem-Sokhn

BAU Journal - Health and Wellbeing

COVID-19 pandemic has emerged over more than 200 countries leading to more than 117 million infection cases and more than 2.6 million deaths. Lebanon is one of the countries affected by this disease especially in the second half of 2020 reaching its peak early this year. In this study, we studied the impact of multiple factors on this surge and analyzed the positive tests among different age groups over a period of one year (from March 2020 to February 2021). Data was collected from one medical center in Beirut where more than 20,000 PCR tests were done using RT-PCR method …

Wellness Review 2021, Part 2, Brian A. Ferguson, Martin Huecker

Journal of Wellness

Introduction: This article presents Part 2 of the biannual JWellness Review of literature from 2021 (July – December). We emphasize new science and resilience initiatives published outside of JWellness that seek understanding of burnout and thriving among healthcare professionals (HCPs).

Methods: For the interval of July 1 to December 30, 2021, PubMed was queried for empirical and observational research studies, review articles, guideline summaries, letters, and editorials. Of 93 results, we reviewed methods and salient points to arrive at a final list of 48 articles for inclusion.

Literature in Review: Common themes that emerged included teamwork, EMR optimization, group decompression, …

Candida Spp. Associated With Covid-19 And Its Susceptibility To Some Antifungals, Mohammed Mudhafar Alkhuzaie, Neeran Obied Jasim

Al-Qadisiyah Journal of Pure Science

The aim of this study was to conduct a survey of the Candida speciesassociated with COVID-19 viral infection in 150 patients who were admitted to the intensive care unit (ICU) in Al-Diwaniyah Teaching Hospital in Al-Diwaniyah City, Iraq, for a five-month period from October 2021 to February 2022. The results indicated the dominance of Candida spp.over the rest of the isolated fungal species, with 97 isolates (64.66%). C. albicans was shown to be the most abundant species with a percentage of 55.67 percent (P 0.05), compared to the other Candida speciesthat were isolated (Candida tropicalis13.4 percent, Candida glabrata12 percent, Candida …

An In Silico Study Of The Cathepsin L Inhibitory Activity Of Bioactive Compounds In Stachytarpheta Jamaicensis As A Covid-19 Drug Therapy, Juliyatin Putri Utami, Nia Kurnianingsih, Mohammad Reza Faisal

Makara Journal of Science

Inhibition of cathepsin L (Cat L) can be considered a target for COVID-19 treatment. Starchytapheta jamaicensis is a plant from the Verbenaceae family that is commonly used for medicinal purposes. This study aims to analyze the inhibitory activities of compounds of Stachytarpheta jamaicensis toward Cat L by computational docking analysis. Ten compounds contained in the extracts (i.e., α-spinasterol, apigenin, luteolol-7-glucuronide, friedelin, hispidulin, chlorogenic acid, ipolamiide, geraniol, hentriacontane, and γ-aminobutyric acid) were selected as ligands; decanoyl-arg-val-lys-arg-chloromethylketone and oxocarbazate were used as the reference. Computational docking analysis was performed using Autodock Vina integrated into PyRx 8.0 and visualized using the Discovery Studio …

Uncharted Territories: Covid-19 And Other 2020 Events That Changed Lives Forever, Justina Ogodo

Journal of Multicultural Affairs

The year 2020 rolled in with pomp and pageantry like any other year in human history. I assume that many like me had high hopes, possibly made new year resolutions. I looked forward to the new year with great expectations—planned trips, events, graduations, weddings, and even new writing goals and aspirations. But the year had its own plan, taking an unexpected turn. I am a science educator, wife, and mother of three black children; I walked into the uncharted territories of COVID-19 and other 2020 events that changed lives forever. I tell this story of my lived experience with a …

Implementation Of A Drive-Through Covid-19 Mass Vaccination Site: Experiences From Louvax–Broadbent In Louisville, Kentucky, Ruth Carrico, Sarah Beth Hartlage, Valenchia Brown Msn, Aprn, Fnp-C, Sarah M. Bishop, Luanne Didelot, William Hayden, Beverly Williams Coleman, Sarah Tan, Delanor Manson, Kellie Kane, Dawn Balcom, Paul Kern

The University of Louisville Journal of Respiratory Infections

Background: Response to the COVID-19 pandemic has required innovative approaches to vaccination, including methods to rapidly and safely immunize communities. A major challenge to such a response involved access to untapped healthcare worker resources. The Louisville, Kentucky, response involved the use of a large volunteer workforce to supplement local public health employees in planning and implementing a large-scale drive-through vaccination event. The objective of this manuscript was to outline processes involved in training a mass immunization workforce and implementating a large-scale COVID-19 community vaccination.

Approach: Competency-based and standardized training was provided for every volunteer before working their shift. Volunteers worked …

Glcms Based Multi-Inputs 1d Cnn Deep Learning Neural Network For Covid-19 Texture Feature Extraction And Classification, Elaf Ali Abbood, Tawfiq A. Al-Assadi

Karbala International Journal of Modern Science

Coronavirus disease 2019 epidemic (COVID-19) is an infectious disease that appeared because of the newest version of discovered coronavirus. The advent and rapid spread of this disease over the world necessitated a concerted effort to contain and eradicate it. Computer Tomography (CT) imaging and X-Ray images are considered as one of the important medical examinations used for disease diagnosis. To speed up and confirm the correctness of the medical diagnosis, many artificial intelligence techniques and machine learning methods are proposed. In this paper, a new and efficient proposed system is introduced to extract appropriate and meaningful features for CT scans …

Higher Education Leadership Development During The Covid-19 Pandemic: An Exploration Of Online Learner Readiness, Kevan W. Lamm, Alyssa Powell, L. Rochelle Sapp, Alexa Lamm

Journal of International Agricultural and Extension Education

The COVID-19 pandemic precipitated profound disruptions across the higher education sector as institutions were forced to restructure entire systems and operate with significantly reduced resources. Most notably, many institutions were forced to transition to fully virtual instruction. The present study examined adult leadership development program participants’ perceptions of online learning readiness during the transition to a fully virtual training environment precipitated by the COVID-19 pandemic. A census of the 2020 LEAD21 class was taken, and perceptions of online learning readiness were collected via a retrospective pre- and post-test. Descriptive and inferential statistics were used. Respondents had the highest levels of …

Training, Trust, And Technology: A Mixed-Methods Study Of Latin American Extension Workers’ Experiences During Covid-19, Pablo Lamiño Jaramillo, Amy Boren-Alpizar, Sarahi Morales Vanegas, Carla Millares-Forno

Journal of International Agricultural and Extension Education

The COVID-19 pandemic has drastically affected people's lives around the world, including agricultural extension workers. To date, few studies have been conducted to understand the adaptation of extension services in Latin American countries during the pandemic. This mixed-methods study explored Latin-American extension professionals’ preparation to implement knowledge-sharing activities and sought to understand extension professionals' responsiveness to COVID-19. The results revealed significant differences in extension responsiveness, between field extension workers and in-office extension workers. Delving into this difference revealed that field extension professionals perceived lower responsiveness because they were not able to continue their pre-pandemic, face-to-face activities in the field with …

Pandemics And Animal Welfare: A Mixed-Methods Inquiry Into How The Covid-19 Pandemic Has Affected The Companion Animal Industry In Northwest Arkansas, Sabrina G. Cox, Isabel Whitehead

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

The first cases of coronavirus reported in the United States came in January 2020 (World Health Organization, 2020). In the two years since then, countries around the world have been affected by COVID-19 and the subsequent social, economic, and mental health issues. Previous research shows that the animal healthcare field is already overrun with burnout, substance abuse, depression, and increased levels of stress (Gardner and Hini, 2006), and the pandemic has only compounded these issues (Mair et al., 2020). Observing a lack of meaningful reporting on the issues affecting veterinary staff led the researchers to investigate staff members’ practices, day- …

The Impact Of Covid-19 On Wildlife Strike Rates In The United States, Dan Parsons, Michael Malouf, Wayne Martin

Human–Wildlife Interactions

Shortly after the COVID-19 pandemic impacted air traffic, industry bodies warned of the potential increase in wildlife strike risk. Prior to the pandemic, wildlife strikes were already a concern to the industry. We sought to evaluate industry warnings using interrupted time series analysis of wildlife strike trends in the United States. Using pre-pandemic wildlife strike trends, we compared a forecast of the expected monthly strike rates through the COVID-19 impact period (March 2020 to December 2020) to the actual wildlife strike rates for the same period. Our results showed an increase in wildlife strike rates in 5 out of the …

Adoptive T-Cell Therapies To Overcome T Cell-Dependent Immune Dysregulations In Covid-19, Sevgi̇ Kalkanli Taş, Merve Sai̇de Uzunoğlu, Ayli̇n Seher Uzunoğlu, Duygu Kirkik, Derya Altunkanat, Nevi̇n Kalkanli

Turkish Journal of Biology

Coronavirus disease 2019 (COVID-19) pandemic has been an important global interest that affected millions of people, and it requires a deep investigation of the disease immunology for developing further therapeutic applications. Adoptive T cell therapy promises to address T cell-dependent immune dysregulation in COVID-19 patients by the generation of specific T cell clones against virus-specific antigens. Additionally, targeting B cell-dependent protection through COVID-19 vaccines, which have been developed in the recent year, possessed sufficient prevention for spreading the virus, since the cases and deaths related to COVID-19 tend to decrease after the vaccination. However, adoptive cell therapies are now encouraging …

Development A Novel Multi-Epitope Dna Vaccine Against Human Sars Coronavirus-2: An Immunoinformatics Designing Study, Afshin Samimi Nemati, Sako Mirzaie, Mohammad Reza Masoumian, Fatemeh Sheikhi, Mostafa Jamalan

Turkish Journal of Biology

Human SARS coronavirus 2 (SARS-CoV-2) causes the current global COVID-19 pandemic. The production of an efficient vaccine against COVID-19 is under heavy investigation. In this study, we have designed a novel multiepitope DNA vaccine against SARS-CoV-2 using reverse vaccinology and DNA vaccine approaches. Applying these strategies led to reduce the time and costs of vaccine development and also improve the immune protective characteristics of the vaccine. For this purpose, epitopes of nucleocapsid, membrane glycoprotein, and ORF8 proteins of SARS-CoV-2 chose as targets for B and T-cell receptors. Accordingly, DNA sequences of selected epitopes have optimized for protein expression in the …

Examining The Experiences Of Small, Independent Grocers During The Covid-19 Pandemic, Jamie Picardy, Lisa Luken, Iris Michaud, Martha Lefebvre

Maine Policy Review

The COVID-19 pandemic has exposed existing vulnerabilities across various sectors of the economy and society. Disruptions to the food chain have been common during the pandemic, resulting in empty shelves at grocery stores and modifications to consumer culture. Within this study, we examined resilience (characterized by flexibility, diversity, redundancy, adaptability, innovation, self-reliance and infrastructure) of small, independent grocery stores in Maine.

Impact Of Covid-19 On Aviation-Wildlife Strikes Across Europe, Isabel C. Metz, Marta Giordano, Dionysios Ntampakis, Marianna Moira, Anneke Hamann, Rosanne Blijleven, Jürgen J. Ebert, Alessandro Montemaggiori

Human–Wildlife Interactions

Collisions between aircraft and wildlife (i.e., wildlife strikes) pose a serious threat toward the safety of aircraft, its crew, and passengers. The effects of COVID-19 related travel restrictions on wildlife strikes are unknown. With this study, we aim to address this information gap by assessing the changes of wildlife hazard management performance across European airports during the lockdown period (e.g., period of reduced operations and borders closure in spring 2020). We also sought to raise awareness of the importance of wildlife strike prevention in times of reduced operations. The objective of our study was to compare wildlife strike data before …