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Changes In Meiotic Crossover Distribution And Frequency In Response To Chromosome Structural Variants, Christiana Wang, Nicole Crown
Changes In Meiotic Crossover Distribution And Frequency In Response To Chromosome Structural Variants, Christiana Wang, Nicole Crown
Intersections Fall 2020
Meiosis is an important mechanism that generates genetic variation for sexually reproducing organisms through recombination. In order for an organism to successfully propagate its genetic material from one generation to the next, its genome must be properly delivered as gametes. Meiotic crossing over of DNA ensures proper homolog segregation by repairing programmed double-stranded breaks. Meiotic defects caused by chromosome structural variants are detrimental to reproduction. During the interchromosomal effect, heterozygous inversions suppress crossing over between affected chromosomes while increasing crossing over between normal chromosome pairs. These defects in chromosomal dynamics trigger the pachytene checkpoint, leading to a delay in prophase …
Genespeak: [Dr. Michael W. Young], None None
Genespeak: [Dr. Michael W. Young], None None
Rockefeller University Research Profiles
Rockefeller University Research Profiles are a series of scientific profiles that were published quarterly, from 1980-1990, by the Rockefeller University. Each issue features the research and achievements of an individual Rockefeller University scientist.