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Full-Text Articles in Life Sciences
Discovering Metabolic Networks Of Bovine Fertilization, Erin Lynn Young
Discovering Metabolic Networks Of Bovine Fertilization, Erin Lynn Young
Undergraduate Honors Capstone Projects
At the time of fertilization, a dramatic change occurs in the oocyte that transforms this cell from a metaphase arrested state into a metabolically active and dynamic state. The view of the flow of biological processes within organisms has recently shifted from that of a linear path to a more complex network. Biological processes are no longer thought of in the simple terms of DNA to RNA, RNA to proteins, and proteins to final activity. It is now known that many biological processes involve interconnected networks and feedback loops in which DNA, RNA, proteins, and metabolites perform specific roles. We …
Modulation Of Fast And Slow Inactivation In Two Cardiac Nav Channel Isoforms By Sdz 211-939, Tyce Jeffrey Kearl
Modulation Of Fast And Slow Inactivation In Two Cardiac Nav Channel Isoforms By Sdz 211-939, Tyce Jeffrey Kearl
Undergraduate Honors Capstone Projects
Here we report a hitherto unknown effect of a synthetic inactivation inhibitor on inactivation in cardiac sodium channels (Nav1.5) from two different species: human and bovine. SDZ 211-93 9 stabilized the slow inactivated-state in both channels as seen by an increased steady-state probability of slow inactivation. SDZ also destabilized the fast-inactivated state and increased the amplitude of persistent currents. SDZ modulated conductance parameters, open-state fast inactivation time constants, and activation kinetics of hNav1.5, but not bNav1.5. These findings will aid future studies designed to elucidate the binding site and molecular mechanisms of inactivation inhibitors …
The Influence Of Fluorescent Light On The Development Of In Vitro Fertilized Bovine Oocytes, Jared Bunch
The Influence Of Fluorescent Light On The Development Of In Vitro Fertilized Bovine Oocytes, Jared Bunch
Undergraduate Honors Capstone Projects
Advances in in vitro fertilization and in vitro culture techniques have allowed considerable progress in identifying physiological requirements of mammalian embryos. Parrish et al. (11) reported a major breakthrough on in vitro fertilization when his group identified heparin as an important factor for the capacitation of spermatozoa. Capacitation is necessary for fertilization of matured oocytes. During the precoculture era of embryos (prior to 1980), the development of early preirnplantation embryos was vary limited regardless of medium, medium supplement, gas atmosphere, osmolarity or pH used (7). Coculture techniques of fertilized oocytes using somatic cells during in vitro production, particularly of bovine …
No Evidence Of Linkage Between 35 Genetic Markers And The Spider Lamb Syndrome Gene In Sheep, Sarah Thornell South
No Evidence Of Linkage Between 35 Genetic Markers And The Spider Lamb Syndrome Gene In Sheep, Sarah Thornell South
Undergraduate Honors Capstone Projects
Spider Lamb Syndrome (SLS) is a semi-lethal congenital disorder affecting the Suffolk and Hampshire sheep breeds. The clinical manifestations of the syndrome include severe skeletal and muscular abnormalities with long, fine-boned legs, curvature of the spine and nasal septum, minimal muscling and severe muscle atrophy. The affected animals have a difficult time walking and most lambs do not survive past the first six months of life. A single autosomal recessive gene causes the disorder. Researchers believe the SLS gene arose as a single source mutation in a popular Suffolk blood line in the 1970s. Heterozygous carriers of the SLS gene …