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Molecular Mechanisims Underlying The Anti-Cancer Activity Of Gum Arabic From Acacia Sp. In Triple-Negative Breast Cancer Cells., Sawsan Yaslam Alyafii
Molecular Mechanisims Underlying The Anti-Cancer Activity Of Gum Arabic From Acacia Sp. In Triple-Negative Breast Cancer Cells., Sawsan Yaslam Alyafii
Theses
Metastatic breast cancer is the leading cause of cancer-related deaths among women worldwide. Triple-negative breast cancer (TNBC) is the most aggressive, accounting for 15-20% of all breast cancer cases. As TNBC cells lack the expression of hormone receptors estrogen receptors (ER) and progesterone receptors (PR) and human epidermal growth factor receptor 2 (HER2), TNBCs are unresponsive to hormonal therapy and often become highly resistant when exposed to standard chemotherapy, which has been identifies as a major obstacle in TNBC treatment. Gum Arabic, a natural exudate produced from plants, is widely used traditionally for religious, cosmetics as well as medical purposes …
Molecular Mechanisims Underlying The Anti-Cancer Activity Of Gum Arabic From Acacia Sp. In Triple-Negative Breast Cancer Cells, Sawsan Yaslam Hussein Alyafii
Molecular Mechanisims Underlying The Anti-Cancer Activity Of Gum Arabic From Acacia Sp. In Triple-Negative Breast Cancer Cells, Sawsan Yaslam Hussein Alyafii
Theses
Metastatic breast cancer is the leading cause of cancer-related deaths among women worldwide. Triple-negative breast cancer (TNBC) is the most aggressive, accounting for 15-20% of all breast cancer cases. As TNBC cells lack the expression of hormone receptors estrogen receptors (ER) and progesterone receptors (PR) and human epidermal growth factor receptor 2 (HER2), TNBCs are unresponsive to hormonal therapy and often become highly resistant when exposed to standard chemotherapy, which has been identified as a major obstacle in TNBC treatment. Gum Arabic, a natural exudate produced from plants, is widely used traditionally for religious, cosmetics as well as medicinal purposes …
Anti-Breast Cancer Effect Of Rhus Coriaria Extract, Khawlah Najib Athamneh
Anti-Breast Cancer Effect Of Rhus Coriaria Extract, Khawlah Najib Athamneh
Theses
Plants have been shown to be an excellent source of new drugs, including anticancer agents. Rhus coriaria, commonly known as sumac, a plant that is known to possess different therapeutic values including anti-oxidant and anti-microbial activities. Here, we investigated the anti-cancer effect of R. coriaria on triple negative MDA-MB-231 cell line. We demonstrated that Rhus coriaria ethanolic extract (RCE) inhibits the proliferation of MDA-MB-231 cell line in a time- and concentration dependent manner. RCE induced senescence and cell cycle arrest at G1 phase. Moreover, no proliferative recovery was detected after RCE removal. Annexin V staining and PARP cleavage analysis revealed …
Anti-Colon Cancer Activity Of Origanum Majorana, Nedaa Faisal Al Tamimi
Anti-Colon Cancer Activity Of Origanum Majorana, Nedaa Faisal Al Tamimi
Theses
In the present project, we extend the previous studies of Origanum majorana by evaluating the anti-cancer potential of this plant extract on proliferation of colon cancer. Toward this, we first evaluated the effect of the plant extract on the proliferation and DNA damage, in vitro, of the human colon cancer HT-29 cell line. We also determine the mechanism by which Origanum majorana induced cell death by this extract using biochemical approach. Our results revealed that O. majorana inhibited the growth of HT-29 cells by effecting the cells viability. Further work showed the ability of the extract to cause DNA damage, …