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Full-Text Articles in Life Sciences
Role Of Autophagy In Acridocarpus Orientalis-Induced Anti-Breast Cancer Activity, Suhib Hisham Ahmed Saeed Altabbal
Role Of Autophagy In Acridocarpus Orientalis-Induced Anti-Breast Cancer Activity, Suhib Hisham Ahmed Saeed Altabbal
Theses
Breast cancer is the most frequently diagnosed cancer in women worldwide. Triple Negative Breast Cancer (TNBC), which lacks the expression of the hormonal Estrogen Receptor (ER) and Progesterone Receptor (PR), and the amplification of Human Epidermal Growth Factor Receptor 2 (HER2), is not responsive to the hormonal therapy. Therefore, chemotherapy and radiotherapy, which cause severe side effects, are the current available choices to treat TNBC. Hence, there is an urgent need to find new therapeutic choices for TNBC. It is estimated that 50% of all drugs in clinical use during the 21st century are natural products and plants derived. …
In-Vitro Analysis Of Potential Autophagy Mediated Safranal-Sorafenib Combined Effect On Hepatocellular Carcinoma, Aaminah Farrukh
In-Vitro Analysis Of Potential Autophagy Mediated Safranal-Sorafenib Combined Effect On Hepatocellular Carcinoma, Aaminah Farrukh
Theses
Hepatocellular carcinoma (HCC) is one of the most commonly occurring cancers worldwide. The risk factors include obesity, hepatitis, alcoholism, smoking etc. One of the biggest associated challenges is the current treatment strategies. The therapeutic options are limited with economical and accessibility challenges, especially with increased HCC incidence. Sorafenib, a multikinase inhibitor, is one of the first FDA approved drugs for HCC. But drug resistance and cancer relapse are a common drawback for this treatment. The need for better treatment is crucial now more than ever. The use of saffron as a potential natural therapeutic option is not a novel strategy. …
Anti-Breast Cancer Effect Of Rhus Coriaria Extract, Khawlah Najib Athamneh
Anti-Breast Cancer Effect Of Rhus Coriaria Extract, Khawlah Najib Athamneh
Theses
Plants have been shown to be an excellent source of new drugs, including anticancer agents. Rhus coriaria, commonly known as sumac, a plant that is known to possess different therapeutic values including anti-oxidant and anti-microbial activities. Here, we investigated the anti-cancer effect of R. coriaria on triple negative MDA-MB-231 cell line. We demonstrated that Rhus coriaria ethanolic extract (RCE) inhibits the proliferation of MDA-MB-231 cell line in a time- and concentration dependent manner. RCE induced senescence and cell cycle arrest at G1 phase. Moreover, no proliferative recovery was detected after RCE removal. Annexin V staining and PARP cleavage analysis revealed …