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Full-Text Articles in Life Sciences
Histological Evaluation Of Offspring Kidneys Following Prenatal Vaping, Lucas Georges, Katelyn Chism, Selma Podbicanin, Isaiah Burciaga, Cynthia Corbitt, Rachel Neal
Histological Evaluation Of Offspring Kidneys Following Prenatal Vaping, Lucas Georges, Katelyn Chism, Selma Podbicanin, Isaiah Burciaga, Cynthia Corbitt, Rachel Neal
The Cardinal Edge
Pregnant women are advised to switch from cigarettes to electronic cigarettes to reduce the toxic effects on the fetus, however little research has been done on the impact of vaping on child development. In this study investigating the impact of inhalation exposure to a commercial product on reproductive and developmental functions, C57BL/6 dams were exposed to vapor from VuseTM e-cigarette golden tobacco pod for 3 hours/day at two puffs per minute throughout gestation (Vape) or to filtered air (Sham). This resulted in smaller litter sizes, along with greater weights for Vape offspring at birth that returned to average by …
The Impact Of Prenatal Vape Exposure On Weanling Liver Gene Expression, Isabella R. Fieger, Cristina Isabel Pauig, Mindy Yin, Anna Lipinski, Barrett Blevins, Tyler Plake, Lucas Georges, Katelyn Chism, Isaiah Burciaga, Selma Podbicanin, Cynthia Corbitt, Rachel Neal
The Impact Of Prenatal Vape Exposure On Weanling Liver Gene Expression, Isabella R. Fieger, Cristina Isabel Pauig, Mindy Yin, Anna Lipinski, Barrett Blevins, Tyler Plake, Lucas Georges, Katelyn Chism, Isaiah Burciaga, Selma Podbicanin, Cynthia Corbitt, Rachel Neal
The Cardinal Edge
The use of E-cigarettes is a fairly recent phenomenon. Vaping is seen as the “healthier” alternative to smoking cigarettes, yet we know little about the developmental toxicity of commercially available vaping products. In the current study, C57Bl/6 mice were exposed to Vuse Alto Golden Tobacco pods (5% nicotine) 4 days before mating and throughout gestation (GD19) for 1 hour/day every day. Offspring birth outcomes were measured with liver tissue collected at weaning. Gross histology and gene expression in the SIRT1-FXR pathway were examined via qPCR analysis with male and female offspring analyzed separately. No differences in gross morphology or cell …