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Full-Text Articles in Life Sciences
Molecular Approaches To The Genetics Of Obesity: Mapping And Characterization Of The Murine Diabetes (Db) Gene, Nathan Bahary
Molecular Approaches To The Genetics Of Obesity: Mapping And Characterization Of The Murine Diabetes (Db) Gene, Nathan Bahary
Student Theses and Dissertations
Studies of twins, adopted children, and some human populations indicate that there is a substantial genetic influence on body composition in both children and adults. However, in no single instance in either man or animals is the precise etiology of obesity known at the molecular level. Attempts to identify the molecular basis responsible for obesity in humans have been hampered by difficulties in measuring food intake and energy expenditure to sufficient accuracy, as well as the apparent polygenic control of body composition in man. These constraints have stimulated interest in the simpler models available in certain inbred animal strains, and …
A Genetic And Molecular Analysis Of The Control Of The Start Of The Cell Cycle In Saccharomyces Cerevisiae, Charles B. Epstein
A Genetic And Molecular Analysis Of The Control Of The Start Of The Cell Cycle In Saccharomyces Cerevisiae, Charles B. Epstein
Student Theses and Dissertations
Progression through the eukaryotic cell cycle is controlled by the CDC28 protein kinase and its homologs. In the budding yeast Saccharomyces cerevisiae, this kinase is required for cell cycle S T A R T (commitment to cell cycle progression late in Gl), and for entry into mitosis. Although constitutively present, CDC28 is only periodically activated. The activation of CDC28 involves its physical association with proteins called cyclins. Budding yeast have three CLN genes (CLNs 1 - 3), which have limited cyclin homology. At least one of the three is required for cell cycle START. Four B cyclins are known in …
Androgen Regulation Of Gene Expression Associated With Cell Growth And Neural Plasticity: Studies In Songbird Brain And The S115 Cell Line, Kent L. Nastiuk
Androgen Regulation Of Gene Expression Associated With Cell Growth And Neural Plasticity: Studies In Songbird Brain And The S115 Cell Line, Kent L. Nastiuk
Student Theses and Dissertations
In order to characterize androgens' effects on the brain and behavior I identified the canary cDNA coding for the nuclear receptor for androgen. The sequence is very conserved over functional domains, but shows some divergence from the only other sequences known, those for rodents and man. The AR mRNA can be localized by in situ hybridization in the canary to the testis and the song nuclei HVc, RA, and MAN. The AR mRNA is regulated by androgens in the periphery in a tissue specific manner. Using a sensitive semi-quantitative per assay, regulation of the AR mRNA by androgen treatment and …
The Role Of Tyrosine Kinase Growth Factor Receptors In Psoriatic Epidermal Hyperplasia: Analysis Of Growth Factor Synergy In Cultured Human Keratinocytes And Receptor Expression In Psoriatic Skin, Jeffrey F. Krane
Student Theses and Dissertations
Psoriasis is a hyperproliferative disease of the skin characterized histologically by epidermal and dermal hyperplasia and inflammatory cell infiltrates. While the pathogenesis of psoriasis is unknown, altered expression of cytokine pathways is likely to produce many of the phenotypic changes in the disease. The epidermal growth factor (EGF) receptor pathway is an important mediator of keratinocyte growth and both ligand and receptorcomponents of this pathway are abnormally expressed in hyperproliferative epidermis. In contrast, little is known about the function of other growth factor pathways in regulating keratinocyte growth. The purpose of this thesis was to characterize the function of three …