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Towards Better Detection And Treatment Of Mycobacterial Disease., Laura O'Connell
Towards Better Detection And Treatment Of Mycobacterial Disease., Laura O'Connell
ORBioM (Open Research BioSciences Meeting)
Background
Mycobacterial disease is a major cause of fatality, with 1.5 million deaths per 10 million infections annually. Due to the emergence of multi- and extensively-drug resistant clinical isolates, mycobacteriophage (MP) are being investigated as an alternative to antibiotics.
Objectives
The objectives of this study were: to characterise an emerging cohort of MP, to determine suitable in vivo modes of delivery for MP including encapsulation, to examine the application of a MP-based viability assay, and to examine the functionality of MP in raw milk.
Methods
The fast-growing Mycobacterium smegmatis was used as a host in all assays to demonstrate phage …
Mycobacteriophage: A Demonstration Of The Reduction Of M. Smegmatis In Various Matrices., Laura O'Connell
Mycobacteriophage: A Demonstration Of The Reduction Of M. Smegmatis In Various Matrices., Laura O'Connell
ORBioM (Open Research BioSciences Meeting)
Background
Mycobacterial disease is a major cause of fatality worldwide, with approximately 1.5 million deaths for every 10 million infections. These infections are difficult to treat due to the intrinsic resistance of its mycolic acid rich cell wall to many antibiotics. There is potential for mycobacteriophage (MP) to be used therapeutically for multidrug- and extensively-drug resistant infections. Mycobacterium smegmatis mc2 155 is a useful substitute for slow-growing pathogenic mycobacteria, as it propagates quickly under lab conditions. This feature of M. smegmatis increases the pace of analysis, by ensuring the quick isolation and characterisation of MP and acting as a …
An Investigation Of The Novel Use Of Bacteriophages To Diagnose And Treat Johne's Disease In Cattle, Max Kevane-Campbell
An Investigation Of The Novel Use Of Bacteriophages To Diagnose And Treat Johne's Disease In Cattle, Max Kevane-Campbell
ORBioM (Open Research BioSciences Meeting)
Johne’s disease is a scourge to dairy farmers all over the world. It is an infectious disease that causes chronic inflammation and lesions along the inside of the small intestine of, primarily, ruminant animals (i.e., cattle and sheep). It is an incurable disease and urgently requires new and radical intervention strategies. Apart from careful on-site farm management practices, little can be offered to farmers to reduce the risk of infection, and nothing short of livestock culling is effective once an animal becomes infected. Currently, there are no vaccines licensed in Ireland or antibiotic treatment strategies available for Johne’s disease. This …