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In Vitro Antimicrobial Activity Of Cell-Free Supernatants From Asymptomatic Bacteriuria (Abu) Isolates Against Multi-Drug Resistant Uropathogenic Escherichia Coli (Upec), Ciara Kenneally
ORBioM (Open Research BioSciences Meeting)
Background
Multi-drug resistant uropathogenic Escherichia coli (UPEC) cause > 80% of community acquired urinary tract infections (UTIs) and > 40% of nosocomial UTIs. Preliminary evidence suggests a beneficial role for UPEC’s commensal counterparts, asymptomatic bacteriuria (ABU), in establishing bacterial interference against UPEC. The aim of this study was to analyse the antimicrobial activity of cell free supernatants (CFS) from ABU isolates against UPEC.
Methods
In vitro antagonistic effects of nine uncharacterised ABU isolates were compared against the inhibitory affect induced by the prototype ABU isolate, E. coli 83972. Turbidimetric growth assays were performed using the CFS of the ABU isolates against eight …