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Monocytes And Macrophages Promote Increased Tissue Factor-Factor Viia-Dependent Procoagulant Activity In Response To The Sars-Cov-2 Spike Protein, James Harte
ORBioM (Open Research BioSciences Meeting)
Background
Venous thromboembolism (VTE) is a high-incidence complication of severe SARS-CoV-2-associated COVID-19. Recently, abnormal tissue factor expression has been linked to thromboembolic events in patients with COVID-19. Monocytes and macrophages are the predominant source of tissue factor in peripheral circulation, which suggests a potential pathomechanistic interplay between SARS-CoV-2 and the monocyte-macrophage axis. However, the link between monocytes and macrophages and the thromboembolic risk associated with COVID-19 is largely unaddressed.
Aims
In this study, we investigated changes in monocyte/macrophage procoagulant activity in response to the SARS-CoV-2 spike protein.
Methods
Immortalised human-derived monocytes and differentiated macrophages were treated with the SARS-CoV-2 spike …