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Dietary Protein Influences Paracellular Calcium Transport: Two Molecular Targets, Belinda M. Kotler
Dietary Protein Influences Paracellular Calcium Transport: Two Molecular Targets, Belinda M. Kotler
Master's Theses
The effect of dietary protein on bone health remains controversial. We have shown that increasing dietary protein increases calcium absorption in both humans and rats with no change in bone resorption. We used a rat model in which dietary protein increases intestinal calcium absorption and whole body calcium retention, to explore the molecular basis for this effect. Female Sprague-Dawley rats were fed a low (5%) or high (40%) protein diet for 7 days. On day 7, duodenal mucosa was harvested and total RNA isolated. Microarray analyses using these RNA samples identified 208 genes whose expression was at least 1.5 fold …