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Full-Text Articles in Life Sciences
The Roles Of Human Cytomegalovirus Us27 Gene Product During Virus Infection, Carolyn C. Tu
The Roles Of Human Cytomegalovirus Us27 Gene Product During Virus Infection, Carolyn C. Tu
Master's Theses
Human cytomegalovirus (HCMV) is a widespread pathogen that causes lifelong latent infection. Successful persistence of HCMV in healthy individuals involves extensive manipulation of host cellular functions and immune responses. HCMV encodes four genes for putative G protein-coupled receptors (GPCRs): US27, US28, UL33, and UL78. The US28 gene product is a functional chemokine receptor that exhibits a variety of signaling outcomes. In contrast, the US27 gene product is an orphan with no known chemokine ligands. We have found that US27 triggers several biological effects: increased cellular proliferation, changes in gene expression, and enhanced signaling of cellular chemokine receptor CXCR4. Enhanced cell …
Detection Of Hcmv Viral Il-10 (Vil-10) In Healthy Blood Donors, Vivian P. Young
Detection Of Hcmv Viral Il-10 (Vil-10) In Healthy Blood Donors, Vivian P. Young
Master's Theses
Human cytomegalovirus (HCMV) is widespread in the general population and can establish lifelong latency with expression of a limited subset of viral genes. The UL111A gene is expressed during both lytic and latent infection, and at least two protein isoforms are produced. During lytic infection, the full length transcript yields cmvIL-10, a potent immunosuppressive viral ortholog of human IL-10 (hIL-10). Alternative splicing of the UL111A transcript yields a truncated protein, LAcmvIL-10, which is expressed during both lytic and latent infection but with a limited range of immunosuppressive functions. The two viral cytokines, collectively termed viral IL-10 (vIL-10), are identical in …