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Effects Of Muscle Cooling On Ampk And Protein Synthesis In Skeletal Muscle, Kyle Lyons, David Thomson, Pdbio
Effects Of Muscle Cooling On Ampk And Protein Synthesis In Skeletal Muscle, Kyle Lyons, David Thomson, Pdbio
Journal of Undergraduate Research
AMP-activated protein kinase (AMPK) is an intracellular protein that regulates many signaling responses including the mechanistic target of rapamycin (mTOR) pathway, which increases protein synthesis1. Recent research suggests that cold-water immersion of the leg activates AMPK in skeletal muscle. It is not known whether cold directly activates AMPK in skeletal muscle or if the aforementioned results are due to systemic or hormonal responses. Furthermore, the direct effect of cooling on protein synthesis-related signaling in skeletal muscle has not been established. If cooling affects the activation of AMPK, then it could also affect mTOR. Therefore, the purpose of this study was …