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Full-Text Articles in Life Sciences
A Review Of How Bioinformatics And Genome Sequencing Are Affecting Precision Medicine, Taylor S. Hickey
A Review Of How Bioinformatics And Genome Sequencing Are Affecting Precision Medicine, Taylor S. Hickey
Honors Theses
Advancement in genomic sequencing and bioinformatics methods have been affecting biomedical research through precision medicine, especially in the area of cancer. Vaccine therapies can be developed using neoantigens that target specific mutations in tumors. The goals of this research are to identify mutations that lead to cancer and then define subpopulations in which patients can easily be identified. The future goal is to have targeted vaccines that are specific to each subpopulation ready to be used in treatment of their cancer. Limitations to reaching these goals have been due to tumor heterogeneity, cancer location, and difficulty in creating neoantigens for …
Adaptations Of Interferon Regulatory Factor 3 During Transition From Terrestrial To Aquatic Life, Monica Angeletti
Adaptations Of Interferon Regulatory Factor 3 During Transition From Terrestrial To Aquatic Life, Monica Angeletti
Honors Theses
Interferon regulatory factor 3 (IRF3) and IRF7 are closely related IRF members and play a major role in the induction of interferons, which are a key component in vertebrate innate immunity. However, there is limited knowledge regarding the evolution and adaptation of these IRFs to the environment. Two unique motifs in IRF3 and 7 were identified. One motif, GASSL, is highly conserved throughout the evolution of IRF3 and 7 and located in the signal response domain. Another motif, DPHK, is in the DNA-binding domain. The ancestral protein of IRF3 and 7 seemed to possess the DPHK motif. In the ray-finned …
Copy Number Variation In The Porcine Genome Detected From Whole-Genome Sequence, Rebecca Anderson
Copy Number Variation In The Porcine Genome Detected From Whole-Genome Sequence, Rebecca Anderson
Honors Theses
Copy number variations (CNVs) are large insertions, deletions, and duplications in the genome that vary between individuals in a species. These variations are known to impact a broad range of phenotypes from molecular-level traits to higher-order clinical phenotypes. CNVs have been linked to complex traits in humans such as autism, attention deficit hyperactivity disorder, nervous system disorders, and early-onset extreme obesity. In this study, whole-genome sequence was obtained from 72 founders of an intensely phenotyped experimental swine herd at the U.S. Meat Animal Research Center (USMARC) in Clay Center, Nebraska. This included 24 boars (12 Duroc and 12 Landrace) and …