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Full-Text Articles in Life Sciences
Metformin Alleviates Hepatic Iron Overload And Ferroptosis Through Ampk-Ferroportin Pathway In Hfd-Induced Nafld, Fangzhi Yue, Ying Shi, Shanyu Wu, Lin Xing, Dan He, Lin Wei, Anqi Qiu, Ryan D. Russell, Dongmei Zhang
Metformin Alleviates Hepatic Iron Overload And Ferroptosis Through Ampk-Ferroportin Pathway In Hfd-Induced Nafld, Fangzhi Yue, Ying Shi, Shanyu Wu, Lin Xing, Dan He, Lin Wei, Anqi Qiu, Ryan D. Russell, Dongmei Zhang
Health & Human Performance Faculty Publications and Presentations
Highlights
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Metformin alleviates HIO and ferroptosis in HFD-induced NAFLD
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FPN is involved in the molecular mechanism of metformin on HIO in HFD-induced NAFLD
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Metformin upregulates FPN expression by reducing lysosomal ubiquitination degradation
Summary
Metformin prevents progression of non-alcoholic fatty liver disease (NAFLD). However, the potential mechanism is not entirely understood. Ferroptosis, a recently recognized nonapoptotic form of regulated cell death, has been reported to be involved in the pathogenesis of NAFLD. Here, we investigated the effects of metformin on ferroptosis and its potential mechanism in NAFLD. We found that metformin prevented the progression of NAFLD, and alleviated hepatic iron …