Life Sciences Commons^™

The Effects Of Physical Function And Genetics On Cognition And Blood Biomarkers In Individuals At-Risk For Alzheimer’S Disease And Related Dementias, Joshua Louis Gills

Graduate Theses and Dissertations

Alzheimer’s disease and related dementia (ADRD) rates are expected to triple by the year 2050. Early detection and specific mitigation efforts are warranted to blunt the alarming rate. Physical function (PF) declines with age, but higher physical function is associated with better cognitive functioning in middle-to- older age individuals. Moreover, greater physical activity (PA) is associated with better global cognition; however, Apoliporotein e4 carriers may not gain the same benefits with exercise. Additionally, plasma phosphorylated tau 217 (p-tau217) has been identified as a novel diagnostic ADRD biomarker which needs further research to examine associations with risk factors. Therefore, the aims …

Validity And Reliability Of A 5-Minute Web-Camera Based Eye Tracking Test To Assess Visual Memory And Cognition, Emily Bates

Graduate Theses and Dissertations

There are approximately 5.7 million Americans currently living with Alzheimer’s Disease (AD). Early detection of cognitive impairment allows for earlier treatment, potentially slowing or halting cognitive decline. A 30-min web-camera eye tracking assessment (30-min VPC) has been validated as a tool to predict AD risk. However, a shorter version would allow for greater scalability and improve user experience. The purpose of this study was to: 1) determine the validity of the 5-minute web-camera based VPC test with the 30-min test, 2) determine the test-retest reliability of the 5-min test, 3) compare the 5-minute test scores of cognitively intact adults (18-39 …

The Effects Of Consuming Eggs On The Physical And Cognitive Development Of Food-Insecure Haitian Children, Monica Elaine Stewart

Graduate Theses and Dissertations

Within Latin America and the Caribbean, severe food insecurity is highest in Haiti. Fifty-five percent of the population lives below the poverty line with approximately 50% of the population undernourished. Given the typical diet in the developing world is primarily plant-based, the two studies presented in this thesis examine how eggs, a locally available animal protein, impact physical growth, cognitive development, and motor skills of food-insecure children from a single orphanage in Leogane, Haiti when added to the diet.

In the first study, growth parameters in children ages 3-8 years old were measured at baseline, six months, and one year. …

The Effects Of Hypohydration On Neurocognitive, Balance, Vestibular Ocular Motor Functions And Mood State, Satoshi Iida

Graduate Theses and Dissertations

Inconsistent findings have been observed on the impact of hydration state on cognitive functions. The isolated effect of hypohydration on neurocognitive performance, balance, vestibular ocular motor function and mood outcomes in widely used concussion assessment tools has not been studied. The purpose of this study was to investigate how hypohydration affected the results in concussion testing batteries. A single-blind randomized crossover design was used. Thirteen healthy males (22 ± 4y, 180.9 ± 5.7cm) without history of concussion within the past six months or any condition or disease that could influence outcome measurements participated in this study. Each subject completed concussion …

Disentangling Embodied Cognition: An Examination Of The State, Problems, And Possibilities Of Embodied Cognition, Cody Cash

Graduate Theses and Dissertations

Embodied cognition has received a fair amount of attention in philosophical, neuroscientific, and robotic research during the past several decades, yet the precise nature of its goals, methods, and claims are unclear. This dissertation will ascertain and examine the primary themes in the field of embodied cognition as well as why, and if, they offer significant challenges to traditional cognitive science models. Though many theories believe they are providing accounts that should replace traditional models, to do so they will have to overcome the very difficult challenge of arguing that mental content and capabilities derived from sensorimotor activity can continue …