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Full-Text Articles in Life Sciences
Sex Differences In Cancer Cachexia And A Novel Mitochondrial Target For Cancer-Induced Muscle Wasting, Seongkyun Lim
Sex Differences In Cancer Cachexia And A Novel Mitochondrial Target For Cancer-Induced Muscle Wasting, Seongkyun Lim
Graduate Theses and Dissertations
Cancer cachexia (CC) is a devastating wasting syndrome characterized by marked weight loss including skeletal muscle atrophy that affects approximately 80% of cancer patients. Current therapeutic treatments including pharmacological and nutritional intervention are insufficient to prevent or reverse it. Prior studies demonstrated lower muscle mass, impaired muscle function, and mitochondrial health in the development of CC. Specifically, mitochondrial fusion protein, Optic atrophy 1 (OPA1) which plays a significant role in skeletal muscle health, is suppressed in the development of CC. Furthermore, most pre-clinical CC studies were mainly focused on males although there are distinct phenotypical differences in skeletal muscle between …
Studying Acetylation Of Aconitase Isozymes By Genetic Code Expansion, Jessica Araujo
Studying Acetylation Of Aconitase Isozymes By Genetic Code Expansion, Jessica Araujo
Graduate Theses and Dissertations
The tricarboxylic acid (TCA) cycle is a very important, centrally located, energy-producing pathway that connects numerous other metabolic and regulatory pathways. Enzymes of this cycle have been more recently implicated in various cancers and neurometabolic disorders, however, the exact mechanism by which this happens becomes quite complex when considering the potential modification of these enzymes and the presence of multiple forms of the enzymes and therefore there is much to be studied in this area.
Aconitase has become a recent enzyme of interest as its substrate, citrate, has been found to play a major role in many vital processes within …