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Mouse Aorta-Derived Mesenchymal Progenitor Cells Contribute To And Enhance The Immune Response Of Macrophage Cells Under Inflammatory Conditions, Jodi F. Evans Ph.D., Veronica Salvador, Sheela George, Cristina Trevino-Gutierrez, Catherine Nunez

Faculty Works: BCES (1999-2023)

Abstract

Introduction: Mesenchymal progenitor cells interact with immune cells and modulate inflammatory responses. The cellular characteristics required for this modulation are under fervent investigation. Upon interaction with macrophage cells, they can contribute to or suppress an inflammatory response. Current studies have focused on mesenchymal progenitors derived from bone marrow, adipose, and placenta. However, the arterial wall contains many mesenchymal progenitor cells, which during vascular disease progression have the potential to interact with macrophage cells. To examine the consequence of vascular-tissue progenitor cell-macrophage cell interactions in an inflammatory environment, we used a recently established mesenchymal progenitor cell line derived from the …