Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (2)
- Other Neuroscience and Neurobiology (2)
- Anesthesiology (1)
- Animal Experimentation and Research (1)
- Chemicals and Drugs (1)
-
- Cognitive Neuroscience (1)
- Computational Neuroscience (1)
- Medical Biophysics (1)
- Medical Sciences (1)
- Medical Specialties (1)
- Neurosciences (1)
- Other Psychiatry and Psychology (1)
- Pharmaceutical Preparations (1)
- Psychiatry and Psychology (1)
- Research Methods in Life Sciences (1)
- Systems Neuroscience (1)
Articles 1 - 4 of 4
Full-Text Articles in Life Sciences
Inter-Subject Correlation Using Movie-Driven Fmri In Drug-Resistant Epilepsy, Hana H. Abbas
Inter-Subject Correlation Using Movie-Driven Fmri In Drug-Resistant Epilepsy, Hana H. Abbas
Electronic Thesis and Dissertation Repository
Treating drug-resistant epilepsy with surgery requires the localization of the epileptic focus. We explored the potential for movie-driven functional magnetic resonance imaging (fMRI) to act as a sensitive, non-invasive, and cost-effective tool to identify functionally disturbed networks. We assessed neural synchronization (inter-subject correlation; ISC) between presurgical epilepsy patients (n = 18) and healthy controls (n = 24) as they watched a suspenseful movie clip in the scanner. To optimize denoising, we compared ISC values with and without an automated Independent Components Analysis-based denoising step (ICA-AROMA). We found that denoising with ICA-AROMA elicited augmented correlation values, supporting its use …
Brain Representations Of Dexterous Hand Control: Investigating The Functional Organization Of Individuated Finger Movements And Somatosensory Integration, Spencer Arbuckle
Brain Representations Of Dexterous Hand Control: Investigating The Functional Organization Of Individuated Finger Movements And Somatosensory Integration, Spencer Arbuckle
Electronic Thesis and Dissertation Repository
Using our hands to manipulate objects in our daily life requires both dexterous movements and the integration of somatosensory information across fingers. Although the primary motor (M1) and somatosensory cortices (S1) are critical for these two complementary roles, it is unclear how neural populations in these regions functionally represent these processes. This thesis examined the functional organization of brain representations (the representational geometry) in M1 and S1 for dexterous hand control and somatosensory processing. To that end, representational geometries were estimated from fine-grained brain activity patterns measured with functional MRI (fMRI). Since fMRI measures a blood-based proxy of neural activity, …
Brain Signatures Of Human Skill Learning: From Single Movements To Movement Sequences, Eva Berlot
Brain Signatures Of Human Skill Learning: From Single Movements To Movement Sequences, Eva Berlot
Electronic Thesis and Dissertation Repository
Sequences of finger movements, such as making a cup of coffee or playing the piano, have a key role in our lives. An important neuroscientific question is how such movement sequences are represented in the brain. The central goal of this thesis was to investigate how different brain regions represent individual movements, and how these representations change when learning sequences of movements. To that end, we used 1) high-field functional magnetic resonance imaging (fMRI) to measure brain activation in humans while they produced finger movements on a keyboard-like device, and 2) advanced multivariate analyses to characterize the brain representations underlying …
Evaluating Anesthetic Protocols For Non-Human Primate Functional Neuroimaging, Megha Verma
Evaluating Anesthetic Protocols For Non-Human Primate Functional Neuroimaging, Megha Verma
Electronic Thesis and Dissertation Repository
Functional magnetic resonance imaging (fMRI) is a non-invasive technique that can be used to measure a proxy of neural activity in vivo with high spatial specificity. One subject can be followed for a long period of time to assess changes in functional brain organization. However, fMRI is extremely sensitive to motion. The challenges of training non-human primates to reduce motion in an MRI scanner motivate the study of anesthesia which is commonly used to substitute for this training. In this thesis, I compare three different commonly used anesthetic protocols: isoflurane, propofol-fentanyl in combination, and fentanyl alone, to test which of …