Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Life Sciences
The Effect Of Aerobic Exercise Training On Cerebrovascular Hsp70, Hsp90, Inos And Enos Expression In Type 1 Diabetes, Adwitia Dey
The Effect Of Aerobic Exercise Training On Cerebrovascular Hsp70, Hsp90, Inos And Enos Expression In Type 1 Diabetes, Adwitia Dey
Electronic Thesis and Dissertation Repository
The purpose of this study was to determine the effect of exercise training alone and in a model of Type 1 Diabetes Mellitus (T1DM), on Heat Shock Protein (HSP) and Nitric Oxide Synthase (NOS) expression in entorhinal adjacent large and small cerebral vessels. Thirty-two rats were randomly allocated to four groups: control sedentary (C), control exercised (CX), diabetic sedentary (D) and diabetic exercised (DX). Exercise training incorporated 5 days/week on a motorized treadmill (27m/min; 6 degree incline; 1 hour) for 10 weeks. Exercise trained groups had significantly greater Hsp70 expression than their respective non-trained groups (p<0.05) and this response was not blunted in T1DM animals. The inducible NOS (iNOS) expression was greater in diabetic sedentary when compared to all other groups (p<0.001). Co-localization of protein with smooth muscle cells illustrates that all HSP and NOS signal content is localized to the smooth muscle area (SMA).
Associations Between Heart Rate Variability And Metabolic Syndrome Risk Factors, Melanie I. Stuckey
Associations Between Heart Rate Variability And Metabolic Syndrome Risk Factors, Melanie I. Stuckey
Electronic Thesis and Dissertation Repository
Metabolic syndrome (MetS) is a clustering of risk factors for cardiovascular disease (CVD) and type 2 diabetes (T2D) – two major causes of morbidity and mortality worldwide. Heart rate variability (HRV) is a non-invasive measure of cardiac autonomic regulation that predicts mortality and morbidity. Additionally, HRV is reduced in CVD, T2D and MetS. As such, HRV has potential to be a novel cardiometabolic risk factor to be included in clinical risk assessment. Therefore, the purpose of this thesis was to examine the relationships between MetS and HRV. A systematic review of cross-sectional studies examining relationships between HRV and MetS was …