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Full-Text Articles in Life Sciences
What Is The Storage Effect, Why Should It Occur In Cancers, And How Can It Inform Cancer Therapy?, Anna K. Miller, Joel S. Brown, David Basanta, Nancy Huntly
What Is The Storage Effect, Why Should It Occur In Cancers, And How Can It Inform Cancer Therapy?, Anna K. Miller, Joel S. Brown, David Basanta, Nancy Huntly
Ecology Center Publications
Intratumor heterogeneity is a feature of cancer that is associated with progression, treatment resistance, and recurrence. However, the mechanisms that allow diverse cancer cell lineages to coexist remain poorly understood. The storage effect is a coexistence mechanism that has been proposed to explain the diversity of a variety of ecological communities, including coral reef fish, plankton, and desert annual plants. Three ingredients are required for there to be a storage effect: (1) temporal variability in the environment, (2) buffered population growth, and (3) species-specific environmental responses. In this article, we argue that these conditions are observed in cancers and that …