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Temporal Dynamics Of Chronic Inflammation On The Cecal Microbiota In Il-10-/- Mice, Anne-Marie C. Overstreet, Amanda Ramer-Tait, Jan S. Suchodolski, Jesse M. Hostetter, Chong Wang, Albert E. Jergens, Gregory J. Phillips, Michael J. Wannemeuhler
Temporal Dynamics Of Chronic Inflammation On The Cecal Microbiota In Il-10-/- Mice, Anne-Marie C. Overstreet, Amanda Ramer-Tait, Jan S. Suchodolski, Jesse M. Hostetter, Chong Wang, Albert E. Jergens, Gregory J. Phillips, Michael J. Wannemeuhler
Department of Food Science and Technology: Faculty Publications
The intestinal microbiota is a critical component of mucosal health as evidenced by the fact that alterations in the taxonomic composition of the gastrointestinal microbiota are associated with inflammatory bowel diseases. To better understand how the progression of inflammation impacts the composition of the gastrointestinal microbiota, we used culture independent taxonomic profiling to identify temporal changes in the cecal microbiota of C3Bir IL-10-/- mice concomitantly with the onset and progression of colitis. This analysis revealed that IL-10-/- mice displayed a biphasic progression in disease severity, as evidenced by histopathological scores and cytokine production. Beginning at 4 weeks of age, pro-inflammatory …