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Full-Text Articles in Life Sciences
Gaba Metabolism Is Crucial For Long-Term Survival Of Anoxia In Annual Killifish Embryos, Daniel E. Zajic, Jason Podrabsky
Gaba Metabolism Is Crucial For Long-Term Survival Of Anoxia In Annual Killifish Embryos, Daniel E. Zajic, Jason Podrabsky
Biology Faculty Publications and Presentations
In most vertebrates, a lack of oxygen quickly leads to irreparable damages to vital organs, such as the brain and heart. However, there are some vertebrates that have evolved mechanisms to survive periods of no oxygen (anoxia). The annual killifish (Austrofundulus limnaeus) survives in ephemeral ponds in the coastal deserts of Venezuela and their embryos have the remarkable ability to tolerate anoxia for months. When exposed to anoxia, embryos of A. limnaeus respond by producing significant amounts of γ-aminobutyric acid (GABA). This study aims to understand the role of GABA in supporting the metabolic response to anoxia. To explore this, …
Metabolomics Analysis Of Annual Killifish (Austrofundulus Limnaeus) Embryos During Aerial Dehydration Stress, Daniel Zajic, Jason Podrabsky
Metabolomics Analysis Of Annual Killifish (Austrofundulus Limnaeus) Embryos During Aerial Dehydration Stress, Daniel Zajic, Jason Podrabsky
Biology Faculty Publications and Presentations
The annual killifish, Austrofundulus limnaeus, survives in ephemeral ponds in the coastal deserts of Venezuela. Persistence through the dry season is dependent on drought-resistant eggs embedded in the pond sediments during the rainy season. The ability of these embryos to enter drastic metabolic dormancy (diapause) during normal development enables A. limnaeus to survive conditions lethal to most other aquatic vertebrates; critical to the survival of the species is the ability of embryos to survive months and perhaps years without access to liquid water. Little is known about the molecular mechanisms that aid in survival of the dry season. This study …