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Sperm Fate Is Promoted By The Mir-44 Microrna Family In The Caenorhabditis Elegans Hermaphrodite Germline, Katherine Ann Maniates, Benjamin S. Olson, Allison L. Abbott

Biological Sciences Faculty Research and Publications

Posttranscriptional regulation of gene expression, typically effected by RNA-binding proteins, microRNAs (miRNAs), and translation initiation factors, is essential for normal germ cell function. Numerous miRNAs have been detected in the germline; however, the functions of specific miRNAs remain largely unknown. Functions of miRNAs have been difficult to determine as miRNAs often modestly repress target mRNAs and are suggested to sculpt or fine tune gene expression to allow for the robust expression of cell fates. In Caenorhabditis elegans hermaphrodites, cell fate decisions are made for germline sex determination during larval development when sperm are generated in a short window before the …