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Full-Text Articles in Life Sciences
Movement Patterns During Functional Activities In People With Chronic Low Back Pain, Quenten Lowell Hooker
Movement Patterns During Functional Activities In People With Chronic Low Back Pain, Quenten Lowell Hooker
Arts & Sciences Electronic Theses and Dissertations
People with chronic LBP display an altered movement pattern where the lumbar spine moves more readily than other joints that can contribute to the activity. The pattern is of particular clinical relevance because across multiple studies the magnitude of altered pattern is associated with LBP and function. One session of motor skill training (MST) during functional activities can improve the altered pattern. However, of the few studies investigating MST for people with LBP, none have examined the short-term or long-term effects of MST on the altered pattern. Additionally, no study has systematically examined if person-specific characteristics moderate the altered pattern …
Freezing Of Gait: Mechanisms, Mechanics, And Management, Peter S. Myers
Freezing Of Gait: Mechanisms, Mechanics, And Management, Peter S. Myers
Arts & Sciences Electronic Theses and Dissertations
Parkinson disease (PD) is a neurodegenerative disease with multiple motor and non-motor symptoms, including postural instability, gait impairments, and cognitive deficits. More than 50% of individuals with PD experience a symptom called freezing of gait (FOG), described as a transient inability to take another step forward. Individuals with PD who experience FOG (freezers) have further postural, gait, and cognitive impairments compared to individuals with PD without FOG (non-freezers). While degeneration of the dopaminergic neurons in the substantia nigra is accepted as the primary etiology of the disease, research shows that the disease has a global impact on the brain, accounting …
Bridging The Translational Gap Between Rodent And Human Pain Research, Tayler Diane Sheahan
Bridging The Translational Gap Between Rodent And Human Pain Research, Tayler Diane Sheahan
Arts & Sciences Electronic Theses and Dissertations
The treatment of chronic pain is an immense clinical and societal burden rooted in the ineffectiveness and adverse side effects of existing analgesics. Extensive efforts have been directed towards the development of novel pain therapies with maximal efficacy and minimal unwanted effects; however, putative therapeutic targets identified in preclinical rodent models rarely translate in clinical trials. The poor translational record of basic pain research findings has been attributed, in part, to the use of suboptimal rodent pain models and behavioral endpoints used to assess putative analgesics, as well as differences in the pharmacological profiles of rodents and humans. The work …
Physical Activity And Maternal And Neonatal Outcomes In Obese Pregnant Women, Rachel Ann Tinius
Physical Activity And Maternal And Neonatal Outcomes In Obese Pregnant Women, Rachel Ann Tinius
Arts & Sciences Electronic Theses and Dissertations
Maternal obesity and physical inactivity during pregnancy are independently associated with unfavorable maternal and neonatal metabolic outcomes. Previous research in non-gravid adults suggests physical activity provides protection from many chronic diseases irrespective of body weight. The primary purposes of this dissertation were to determine the impact of obesity on maternal metabolic health (lipid metabolism, inflammation, insulin resistance) and neonatal metabolic health (adiposity, inflammation, insulin resistance), and to determine if adverse maternal and neonatal metabolic health is improved in obese pregnant women who are physically active during pregnancy compared to sedentary obese women. The secondary purpose of this dissertation was to …