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Antimicrobial Action Of 1,10-Phenanthroline-Based Compoundson Carbapenemase-Producing Acinetobacter Baumannii Clinical Strains: Efficacy Against Planktonic- And Biofilm-Growing Cells, Roberta F. Ventura, Anna Clara M. Galdino, Livia Viganor, Ricardo P. Schuenck, Michael Devereux, Malachy Mccann, André L.S. Santos, Ana Paula F. Nunes
Antimicrobial Action Of 1,10-Phenanthroline-Based Compoundson Carbapenemase-Producing Acinetobacter Baumannii Clinical Strains: Efficacy Against Planktonic- And Biofilm-Growing Cells, Roberta F. Ventura, Anna Clara M. Galdino, Livia Viganor, Ricardo P. Schuenck, Michael Devereux, Malachy Mccann, André L.S. Santos, Ana Paula F. Nunes
Articles
Therapeutic options are limited for patients infected with Acinetobacter baumannii due to its multidrug-resistance profile. So, the search for new antimicrobials against this gram-negative bacterial pathogen has become a worldwide priority. The present study aimed to evaluate the effects of 1,10-phenanthroline (phen), 1,10-phenanthroline-5,6-dione (phendione), [Ag(phendione)2]ClO4 (Ag-phendione) and [Cu(phendione)3](ClO4)2.4H2O (Cu-phendione) on 26 carbapenemase-producing A. baumannii strains. The susceptibility to carbapenems was performed by detecting the metallo-beta-lactamase (MBL) genes by PCR and by determining the MIC. Also, disk diffusion method was applied to evaluate the susceptibility to other antimicrobial classes. The test compounds were evaluated on both planktonic- and biofilm-growing bacterial cells. …
Structural Features Of 1,3,4-Thiadiazole-Derived Ligands And Their Zn(Ii) And Cu(Ii) Complexes Which Demonstrate Synergistic Antibacterial Effects With Kanamycin, Dariusz Karcz, Arkadiusz Matwijczuk, Daniel Kaminski, Bernadette Creaven, Katarzyna Lecka-Szlachta, Karolina Starzak
Structural Features Of 1,3,4-Thiadiazole-Derived Ligands And Their Zn(Ii) And Cu(Ii) Complexes Which Demonstrate Synergistic Antibacterial Effects With Kanamycin, Dariusz Karcz, Arkadiusz Matwijczuk, Daniel Kaminski, Bernadette Creaven, Katarzyna Lecka-Szlachta, Karolina Starzak
Articles
Classical synthetic protocols were applied for the isolation of three novel 1,3,4-thiadiazole derivatives which were then complexed with the biologically important Cu(II) and Zn(II) ions. All free ligands and their corresponding complexes were characterized using a number of spectroscopic techniques including Ultraviolet-visible (UV–vis), Fluorescence, Infrared (FT-IR), tandem liquid chromatography-mass (LC-MS), X-ray diffraction (XRD), and Nuclear Magnetic Resonance (NMR) spectroscopy (1H, 13C, HSQC, HMBC). The results obtained are consistent with the formation of dihydrate complexes, in which the chelation of the metal ion occurs via one of the thiadiazole nitrogen atoms and the deprotonated hydroxyl group of the …