Life Sciences Commons^™

Immunosuppression By Aflatoxin B1 In C57bl/6 Mice And Its Relationship With Neuroendocrine Mechanisms, Yasuhiko Hatori

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Aflatoxin B₁ (AFB₁), a secondary metabolite of Aspergillus flavus and Aspergillus parasiticus, is known for its potent carcinogenicity and immunosuppressive effects. It is also known that AFB₁ toxicity appears in different degrees in different animal species and strains.

The present study was performed to reveal the involvement of the hypothalamus-pituitary-adrenal gland (HPA) axis in the immunosuppressive effects of AFB₁ on C57BL/6 mice. Splenic lymphocytes were assayed to investigate their phenotyping using flow cytometry, proliferative response against mitogen and allogenic lymphocytes, cytolytic cell activity, and IL-2 production. In addition, antibody-mediated immunocompetence was checked using sheep …

Carbon Dioxide Toxicity In Wheat, Robert Spanarkel

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This research was conducted to quantify short- and long-term effects of atmospheric carbon dioxide on wheat. Growth, development, and yield of the spring wheat cultivar Veery-10 were measured in response to CO₂ concentrations of 340 (ambient), 1200, and 2500 μmol moI^-1 of CO₂ air. These 3 CO₂ levels were chosen to provide a control group, a predicted optimal CO₂ environment, and a potentially toxic CO₂environment, respectively. A recirculating hydroponic system provided a near-optimal root-zone environment that was identical for all CO₂ treatment levels. Environmental factors, other than CO₂, were …