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Full-Text Articles in Life Sciences
Exploring The Impact Of Knowledge And Social Environment On Influenza Prevention And Transmission In Midwestern United States High School Students, William L. Romine, Tanvi Banerjee, William S. Barrow, William R. Folk
Exploring The Impact Of Knowledge And Social Environment On Influenza Prevention And Transmission In Midwestern United States High School Students, William L. Romine, Tanvi Banerjee, William S. Barrow, William R. Folk
Kno.e.sis Publications
We used data from a convenience sample of 410 Midwestern United States students from six secondary schools to develop parsimonious models for explaining and predicting precautions and illness related to influenza. Scores for knowledge and perceptions were obtained using two-parameter Item Response Theory (IRT) models. Relationships between outcome variables and predictors were verified using Pearson and Spearman correlations, and nested [student within school] fixed effects multinomial logistic regression models were specified from these using Akaike’s Information Criterion (AIC). Neural network models were then formulated as classifiers using 10-fold cross validation to predict precautions and illness. Perceived barriers against taking precautions …
Expression Of Inflamatory Response Genes In Ferrets Challenged With H5n1 Avian Influenza Virus, Brock M. Miniard
Expression Of Inflamatory Response Genes In Ferrets Challenged With H5n1 Avian Influenza Virus, Brock M. Miniard
Browse all Theses and Dissertations
Influenza A H5N1 has emerged as a potential to be the next pandemic influenza. Ferrets are a promising model of H5N1 infection because the disease progression is similar to that known in humans, however reagents to characterize infections in ferrets are few. We developed real-time PCR assays for the ferret cytokines IL-1β, IL-2, IL-4, IL-8, IL-12p40, TNF-α, IFN-α, IFN-β, IFN-γ, TGFB-β1, and TGFB-β2. Forty-eight ferrets were vaccinated with either one of three vaccine formulations (Vaccine 1, Vaccine 2, or Vaccine 3), or saline (0.9% NaCl), then challenged intranasally with a lethal dose of H5N1 strain A/Vietnam/1203/04. Cytokine assays were then …