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Full-Text Articles in Life Sciences
Homing Behavior Of Musk Turtles In A Virginia Lake, Randolph Chambers
Homing Behavior Of Musk Turtles In A Virginia Lake, Randolph Chambers
Arts & Sciences Articles
For nine weeks during the summer of 2002, a mark and recapture technique was used to study homing behavior of Musk Turtles (Sternotherus odoratus) living in Lake Matoaka, VA. During the first three weeks of the study, 119 turtles (83 male, 36 female) were captured using unbaited crabpots, then marked and displaced from the site of capture. Turtles were displaced 100 m across open water 4 m deep, 520 m along the same shore, or 550 m across open water. For the last six weeks of the study, 110 turtles (65 males, 45 females) were captured and released with no …
Cancer Promoted By The Oncoprotein V-Erba May Be Due To Subcellular Mislocalization Of Nuclear Receptors, Ghislain M.C. Bonamy, Anne Guiochon-Mantel, Lizabeth A. Allison
Cancer Promoted By The Oncoprotein V-Erba May Be Due To Subcellular Mislocalization Of Nuclear Receptors, Ghislain M.C. Bonamy, Anne Guiochon-Mantel, Lizabeth A. Allison
Arts & Sciences Articles
The retroviral v-ErbA oncoprotein is a highly mutated variant of the thyroid hormone receptor α (TRα), which is unable to bind T3 and interferes with the action of TRα in mammalian and avian cancer cells. v-ErbA dominant-negative activity is attributed to competition with TRα for T3-responsive DNA elements and/or auxiliary factors involved in the transcriptional regulation of T3-responsive genes. However, competition models do not address the altered subcellular localization of v-ErbA and its possible implications in oncogenesis. Here, we report that v-ErbA dimerizes with TRα and the retinoid X receptor and sequesters a significant fraction …
Sodium And Calcium Current-Mediated Pacemaker Neurons And Respiratory Rhythm Generation, Christopher A. Del Negro, Consuelo Morgado-Valle, John A. Hayes, Devin D. Mackay, Ryland W. Pace, Erin A. Crowder, Jack L. Feldman
Sodium And Calcium Current-Mediated Pacemaker Neurons And Respiratory Rhythm Generation, Christopher A. Del Negro, Consuelo Morgado-Valle, John A. Hayes, Devin D. Mackay, Ryland W. Pace, Erin A. Crowder, Jack L. Feldman
Arts & Sciences Articles
The breathing motor pattern in mammals originates in brainstem networks. Whether pacemaker neurons play an obligatory role remains a key unanswered question. We performed whole-cell recordings in the pre-Botzinger complex in slice preparations from neonatal rodents and tested for pacemaker activity. We observed persistent Na+ current (INaP)-mediated bursting in ∼5% of inspiratory neurons in postnatal day 0 (P0)-P5 and in P8-P10 slices. INaP-mediated bursting was voltage dependent and blocked by 20 μm riluzole (RIL). We found Ca2+ current (ICa)-dependent bursting in 7.5% of inspiratory neurons in P8-P10 slices, but in …