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Bacterial Protein Meta-Interactomes Predict Cross-Species Interactions And Protein Function, J. Harry Caufield, Christopher Wimble, Semarjit Shary, Stefan Wuchty, Peter Uetz

Study of Biological Complexity Publications

Background

Protein-protein interactions (PPIs) can offer compelling evidence for protein function, especially when viewed in the context of proteome-wide interactomes. Bacteria have been popular subjects of interactome studies: more than six different bacterial species have been the subjects of comprehensive interactome studies while several more have had substantial segments of their proteomes screened for interactions. The protein interactomes of several bacterial species have been completed, including several from prominent human pathogens. The availability of interactome data has brought challenges, as these large data sets are difficult to compare across species, limiting their usefulness for broad studies of microbial genetics and …