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Full-Text Articles in Life Sciences
Shortest-Path Network Analysis Is A Useful Approach Toward Identifying Genetic Determinants Of Longevity, J. R. Managbanag, Tarynn M. Witten, Danail Bonchev, Lindsay A. Fox, Mitsuhiro Tsuchiya, Brian K. Kennedy, Matt Kaeberlein
Shortest-Path Network Analysis Is A Useful Approach Toward Identifying Genetic Determinants Of Longevity, J. R. Managbanag, Tarynn M. Witten, Danail Bonchev, Lindsay A. Fox, Mitsuhiro Tsuchiya, Brian K. Kennedy, Matt Kaeberlein
Study of Biological Complexity Publications
Background
Identification of genes that modulate longevity is a major focus of aging-related research and an area of intense public interest. In addition to facilitating an improved understanding of the basic mechanisms of aging, such genes represent potential targets for therapeutic intervention in multiple age-associated diseases, including cancer, heart disease, diabetes, and neurodegenerative disorders. To date, however, targeted efforts at identifying longevity-associated genes have been limited by a lack of predictive power, and useful algorithms for candidate gene-identification have also been lacking.
Methodology/Principal Findings
We have utilized a shortest-path network analysis to identify novel genes that modulate longevity in Saccharomyces …