Life Sciences Commons^™

Sickness Behaviors Across Vertebrate Taxa: Proximate And Ultimate Mechanisms, Patricia C. Lopes, Susannah S. French, Douglas C. Woodhams, Sandra A. Binning

Biology Faculty Publications

There is nothing like a pandemic to get the world thinking about how infectious diseases affect individual behavior. In this respect, sick animals can behave in ways that are dramatically different from healthy animals: altered social interactions and changes to patterns of eating and drinking are all hallmarks of sickness. As a result, behavioral changes associated with inflammatory responses (i.e. sickness behaviors) have important implications for disease spread by affecting contacts with others and with common resources, including water and/or sleeping sites. In this Review, we summarize the behavioral modifications, including changes to thermoregulatory behaviors, known to occur in vertebrates …

Characterization Of A Novel Stat 2 Knock Out Hamster Model Of Crimean Congo Hemorrhagic Fever Virus Pathogenesis, Charlene Ranadheera, Emelissa J. Valcourt, Bryce M. Warner, Guillaume Poliquin, Kyle Rosenke, Kathy Frost, Kevin Tierney, Greg Saturday, Jinxin Miao, Jonna B. Westover, Brian B. Gowen, Stephanie Booth, Heinz Feldmann, Zhongde Wang, David Safronetz

Animal, Dairy, and Veterinary Science Faculty Publications

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen causing a febrile illness in humans, which can progress to hemorrhagic manifestations, multi-organ failure, and death. Current mouse models of CCHFV infection reliably succumb to virus challenge but vary in their ability to reflect signs of disease similar to humans. In this study, we established a signal transducer and activator of transcription 2 (STAT2) knockout hamster model to expand the repertoire of animal models of CCHFV pathogenesis that can be used for therapeutic development. These hamsters demonstrated a systemic and lethal disease in response to infection. Hallmarks of human …

Fetal Demise And Failed Antibody Therapy During Zika Virus Infection Of Pregnant Macaques, Diogo M. Magnani, Thomas F. Rogers, Nicholas J. Maness, Nathan D. Grubaugh, Nathan Beutler, Varian K. Bailey, Lucas Gonzalez-Nieto, Martin J. Gutman, Núria Pedreño-Lopez, Jaclyn M. Kwal, Michael J. Ricciardi, Tereance A. Myers, Justin G. Julander, Rudolf P. Bohm, Margaret H. Gilbert, Faith Schiro, Pyone P. Aye, Robert V. Blair, Mauricio A. Martins, Kathrine P. Falkenstien, Amitinder Kaur, Christine L. Curry, Esper G. Kallas, Ronald C. Desrosiers, Pascal J. Goldschmidt-Clermont, Stephen S. Whitehead, Kristian G. Andersen, Myrna C. Bonaldo, Andrew A. Lackner, Antonito T. Panganiban, Dennis R. Burton, David I. Watkins

Animal, Dairy, and Veterinary Science Faculty Publications

Zika virus (ZIKV) infection of pregnant women is associated with pathologic complications of fetal development. Here, we infect pregnant rhesus macaques (Macaca mulatta) with a minimally passaged ZIKV isolate from Rio de Janeiro, where a high rate of fetal development complications was observed. The infection of pregnant macaques with this virus results in maternal viremia, virus crossing into the amniotic fluid (AF), and in utero fetal deaths. We also treated three additional ZIKV-infected pregnant macaques with a cocktail of ZIKV-neutralizing human monoclonal antibodies (nmAbs) at peak viremia. While the nmAbs can be effective in clearing the virus from …

Small-Animal Models Of Zika Virus, Justin G. Julander, Venkatraman Siddharthan

Animal, Dairy, and Veterinary Science Faculty Publications

Zika virus (ZIKV) infection can result in serious consequences, including severe congenital manifestations, persistent infection in the testes and neurologic sequelae. After a pandemic emergence, the virus has spread to much of the new world and has been introduced to many countries outside of endemic areas as infected travelers return to their home countries. Rodent models have been important in gaining a better understanding of the wide range of disease etiologies associated with ZIKV infection and for the initial phase of developing countermeasures to prevent or treat viral infections. We discuss herein the advantages and disadvantages of small animal models …

Development Of A New Tacaribearenavirus Infection Model And Its Use To Explore Antiviral Activity Of A Novelaristeromycin Analog, Brian B. Gowen, M. H. Wong, D. Larson, W. Ye, K. H. Jung, E. J. Sefing, Ramona T. Skirpstunas, Donald F. Smee, John D. Morrey, S. W. Schneller

Animal, Dairy, and Veterinary Science Faculty Publications

Background

A growing number of arenaviruses can cause a devastating viral hemorrhagic fever (VHF) syndrome. They pose a public health threat as emerging viruses and because of their potential use as bioterror agents. All of the highly pathogenic New World arenaviruses (NWA) phylogenetically segregate into clade B and require maximum biosafety containment facilities for their study. Tacaribe virus (TCRV) is a nonpathogenic member of clade B that is closely related to the VHF arenaviruses at the amino acid level. Despite this relatedness, TCRV lacks the ability to antagonize the host interferon (IFN) response, which likely contributes to its inability to …

Antiviral Activities Andphosphorylation Of 5-Halo-2'-Deoxyuridines And N-Methanocarbathymidine In Cells Infectedwith Vaccinia Virus, Donald F. Smee, D. E. Humphreys, B. L. Hurst, Dale L. Barnard

Animal, Dairy, and Veterinary Science Faculty Publications

The Antipoxviral activities and phosphorylation of N-methanocarbathymidine ([N]-MCT) and four 5-halo-2'-deoxyuridines, namely 5-flouro- (FdU), 5-chloro- (CldU), 5-bromo- (BrdU), and 5-iodo- (IdU) derivatives were explored.

What Is That Grayish White Material On My Plants?, Scott Ockey

All Archived Publications

No abstract provided.

What Are Those Large Round Fungus Balls That Appeared In My Lawn Late Last Summer, And What Can I Do To Prevent Their Return?, Jerry Goodspeed

All Archived Publications

No abstract provided.

The Blight Stuff, Dennis Hinkamp

All Archived Publications

No abstract provided.

Cantagious Foot Rot Of Sheep, Clell V. Bagley

All Archived Publications

No abstract provided.

Infection Of Engelmann-Spruce Seed By Geniculodendron Pyriforme In Western North America, M W. Wicklow-Howard

T.W. "Doc" Daniel Experimental Forest

Geniculodendron pyriforme Salt was identified and characterized by Salt (1974) as the fungus responsible for germination failure of Sitka spruce [Picea sitchensis (Bong.) Carr.] seed in Canadian and British forest nurseries. It was confirmed that the fungus isolated by Epners (1964) from seed of Pinus resinosa Ait., P. sylvestris L., P. strobus L., and Picea glauca (Moench.) Voss. in Canadian nurseries was the same (Salt, 1974). In addition, Salt (1970) demonstrated that the pathogen can infect seeds of western hemlock [Tsuga heterophylla (Raf.) Sarg.], lodgepole pine (Pinus contorta Doug!. ex Loud.), Japanese larch [Larix leptolepis (Sieb. and Zucc.) Gord.] and …

Hypoxylon Canker Incidence On Pruned And Unpruned Aspen, Michael E. Ostry, G.W. Anderson

Aspen Bibliography

This sturdy was designed to measure the relation between the incidence of Hypoxylon canker, Hypoxylon mammatum Wahl. Mill., and the presence of branches on an aspen stem.

The Effects Of Dcpa And Trifluralin On Northern Root-Knot Nematode (Meloidogyne Hapla Chitwood) Infection Of Selected Vegetables, Rulon Kent Romney

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The interaction of herbicides and Northern root-knot nematodes (Meloidogyne hapla Chitwood) on onions and beans was studied in the greenhouse. Seeds of onions (Allium cepa L.) were planted in soil treated with different levels of dimethyl 2,3,5,6-tetrachloroterephthalate (DCPA). Seeds of beans (Phaseolus vulgaris L.) were planted in soil treated with different levels of DCPA or α, α, α-trifluoro-2,6-dinitro-N,N-dipropyl-p-toluidine (trifluralin). Seedlings were inoculated with root-knot nematode larvae after 2 week's growth.

DCPA reduced root and shoot growth on onions but did not significantly affect bean growth. Trifluralin significantly reduced root and shoot …

The Initiation Of Infection By Dna From Bacteriophage Lambda, Gerald D. Elseth

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Deoxyribonucleic acid isolated from bacteriophage λ can infect Escherichia coli K12 in the presence of adsorbed helper phage (Kaiser and Hogness, 1960; Kaiser, 1962). The manner in which λ DNA enters the cell and the possible role of helper phage in the penetration process is still not clear. Kinetic studies conducted in this laboratory during the initial stages of infection by λ DNA demonstrate a requirement for helper function during the penetration of an infectious molecule. Further investigation into this problem is needed and was the major objective of this study.