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Use Of Pre-S Protein-Containing Hepatitis B Virus Surface Antigens And A Powerful Adjuvant To Develop An Immune Therapy For Chronic Hepatitis B Virus Infection, J S. Yum, B C. Ahn, H J. Jo, D Y. Kim, K H. Kim, H S. Kim, Y C. Sung, J Yoon, John D. Morrey, H M. Moon
Use Of Pre-S Protein-Containing Hepatitis B Virus Surface Antigens And A Powerful Adjuvant To Develop An Immune Therapy For Chronic Hepatitis B Virus Infection, J S. Yum, B C. Ahn, H J. Jo, D Y. Kim, K H. Kim, H S. Kim, Y C. Sung, J Yoon, John D. Morrey, H M. Moon
John D. Morrey
A hepatitis B virus (HBV) vaccine has been developed using a new adjuvant and HBV surface antigens produced from a CHO cell line. The purified HBV surface antigens are composed of L protein, M protein, and S protein in a mixture of 20- and 40-nm diameter particles and filamentous forms. This HBV surface antigen, formulated with L-pampo, a proprietary adjuvant, induced 10 times more antibody than the same antigen with alum and was capable of inducing strong immune responses in three different HBV transgenic mice. In spite of the presence of a large amount of HBV antigen in the blood, …
Effect Of Dipterinyl Calcium Pentahydrate On Hepatitis B Virus Replication In Transgenic Mice, P Moheno, John D. Morrey, D Fuchs
Effect Of Dipterinyl Calcium Pentahydrate On Hepatitis B Virus Replication In Transgenic Mice, P Moheno, John D. Morrey, D Fuchs
John D. Morrey
Dipterinyl calcium pentahydrate (DCP) has previously been shown to inhibit MDA-MB-231 human breast cancer xenographs in nude mice in a manner correlated with increases in plasma IL-12 and IL-4 concentrations, and decreases in plasma IL-6 levels. DCP also inhibits indoleamine 2,3-dioxygenase (IDO), an immuno-inhibitory enzyme, in human PBMCs (Peripheral Blood Mononuclear Cells).
Alkoxyalkyl Esters Of 9-(S)-(3-Hydroxy-2-Phosphonomethoxypropyl) Adenine Are Potent And Selective Inhibitors Of Hepatitis B Virus (Hbv) Replication In Vitro And In Hbv Transgenic Mice In Vivo, John D. Morrey, B E. Korba, J R. Beadle, D L. Wyles, K Y. Hostetler
Alkoxyalkyl Esters Of 9-(S)-(3-Hydroxy-2-Phosphonomethoxypropyl) Adenine Are Potent And Selective Inhibitors Of Hepatitis B Virus (Hbv) Replication In Vitro And In Hbv Transgenic Mice In Vivo, John D. Morrey, B E. Korba, J R. Beadle, D L. Wyles, K Y. Hostetler
John D. Morrey
Alkoxyalkyl esters of acyclic nucleoside phosphonates have previously been shown to have increased antiviral activity when they are administered orally in animal models of viral diseases, including lethal infections with vaccinia virus, cowpox virus, ectromelia virus, murine cytomegalovirus, and adenovirus. 9-(S)-(3-Hydroxy-2-phosphonomethoxypropyl)adenine [(S)-HPMPA] was previously shown to have activity against hepatitis B virus (HBV) in vitro. To assess the effect of alkoxyalkyl esterification of (S)-HPMPA, we prepared the hexadecyloxypropyl (HDP), 15-methyl-hexadecyloxypropyl (15M-HDP), and octadecyloxyethyl (ODE) esters and compared their activities with the activity of adefovir dipivoxil in vitro and in vivo. Alkoxyalkyl esters of (S)-HPMPA were 6 to 20 times more …