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Investigating The Role Of Transcription Factor Ap-2�� In Reproduction, Anne Rachelle Howlett
Investigating The Role Of Transcription Factor Ap-2�� In Reproduction, Anne Rachelle Howlett
Undergraduate Honors Capstone Projects
The proper formation of gametes is critical for the propagation of species and for the fertility of the individual. The molecular pathways involved in gamete formation remains elusive, therefore, identification of genes involved is an important prerequisite to further our understanding of reproduction. This research will improve infertility treatments and prevention methods in animals and humans. We created mutants that lacked AP-2�� transcription factor after the mouse had entered meiosis and initiated folliculogenesis. The AP-2�� mutants were still fertile and phenotypically similar to normal mice that expressed AP-2�� transcription factor. We also produced mutants that lacked AP-2�� transcription factor during …