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Full-Text Articles in Life Sciences
Common Genetic Variants Found In Hla And Kir Immune Genes In Autism Spectrum Disorder, Anthony R. Torres, Thayne Sweeten, Randall C. Johnson, Dennis Odell, Jonna B. Westover, Patricia Bray-Ward, David C. Ward, Christopher J. Davies, Aaron J. Thomas, Lisa A. Croen, Michael Benson
Common Genetic Variants Found In Hla And Kir Immune Genes In Autism Spectrum Disorder, Anthony R. Torres, Thayne Sweeten, Randall C. Johnson, Dennis Odell, Jonna B. Westover, Patricia Bray-Ward, David C. Ward, Christopher J. Davies, Aaron J. Thomas, Lisa A. Croen, Michael Benson
Institute for Disability Research, Policy & Practice Publications
The “common variant—common disease” hypothesis was proposed to explain diseases with strong inheritance. This model suggests that a genetic disease is the result of the combination of several common genetic variants. Common genetic variants are described as a 5% frequency differential between diseased vs. matched control populations. This theory was recently supported by an epidemiology paper stating that about 50% of genetic risk for autism resides in common variants. However, rare variants, rather than common variants, have been found in numerous genome wide genetic studies and many have concluded that the “common variant—common disease” hypothesis is incorrect. One interpretation is …
Prenataland Newborn Immunoglobulin Levels From Mother-Child Pairs And Risk Of Autismspectrum Disorders, Judith K. Grether, Paul Ashwood, Judy Van De Water, Robert H. Yolken, Meredith C. Anderson, Anthony T. Torres, Jonna B. Westover, Aimee G. Tallian, Robin L. Hansen, Martin Kharrazi, Lisa A. Croen
Prenataland Newborn Immunoglobulin Levels From Mother-Child Pairs And Risk Of Autismspectrum Disorders, Judith K. Grether, Paul Ashwood, Judy Van De Water, Robert H. Yolken, Meredith C. Anderson, Anthony T. Torres, Jonna B. Westover, Aimee G. Tallian, Robin L. Hansen, Martin Kharrazi, Lisa A. Croen
Biology Faculty Publications
Background: An etiological role for immune factors operating during early brain development in children with autism spectrum disorders (ASD) has not yet been established. A major obstacle has been the lack of early biologic specimens that can be linked to later diagnosis. In a prior study, we found lower risk of ASD associated with higher levels of maternally-derived total IgG and Toxoplasmosis gondii (Toxo) IgG in newborn blood spot specimens from children later diagnosed with ASD compared to population controls. Methods: We obtained maternal mid-gestational serum specimens and newborn screening blood spots from the California Genetics Disease Screening Program (GDSP) …