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Role Of Proneurotrophin-P75ntr Signaling In A Mouse Model Of Depression, Kirsten Hodgson

All Graduate Theses and Dissertations, Fall 2023 to Present

Major depressive disorder, or depression, is among the leading causes of disability globally. Despite being a large public health challenge, depression remains difficult to treat as the underlying biology is still unknown and the currently available treatments are limited in effectiveness. This experiment was to test the efficacy of the drug LM11A-31, which works on the signaling pathway of proneurotrophin-p75NTR, a pathway that is not targeted by any currently used antidepressants. Male mice underwent a repeated forced swim, with all the mice receiving saline the first two days and then half the mice receiving saline and half receiving LM11A-31 before …