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Role Of Accelerated Segment Switch In Exons To Alter Targeting (Asset) In The Molecular Evolution Of Snake Venom Proteins, Robin Doley, Stephen P. Mackessy, R. Manjunatha Kini
Role Of Accelerated Segment Switch In Exons To Alter Targeting (Asset) In The Molecular Evolution Of Snake Venom Proteins, Robin Doley, Stephen P. Mackessy, R. Manjunatha Kini
Biological Sciences Faculty Publications
BACKGROUND: Snake venom toxins evolve more rapidly than other proteins through accelerated changes in the protein coding regions. Previously we have shown that accelerated segment switch in exons to alter targeting (ASSET) might play an important role in its functional evolution of viperid three-finger toxins. In this phenomenon, short sequences in exons are radically changed to unrelated sequences and hence affect the folding and functional properties of the toxins.
RESULTS: Here we analyzed other snake venom protein families to elucidate the role of ASSET in their functional evolution. ASSET appears to be involved in the functional evolution of three-finger toxins …