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The Venom Gland Transcriptome Of The Desert Massasauga Rattlesnake (Sistrurus Catenatus Edwardsii): Towards An Understanding Of Venom Composition Among Advanced Snakes (Superfamily Colubroidea), Susanta Pahari, Stephen P. Mackessy, R. Manjunatha Kini
The Venom Gland Transcriptome Of The Desert Massasauga Rattlesnake (Sistrurus Catenatus Edwardsii): Towards An Understanding Of Venom Composition Among Advanced Snakes (Superfamily Colubroidea), Susanta Pahari, Stephen P. Mackessy, R. Manjunatha Kini
Biological Sciences Faculty Publications
BACKGROUND: Snake venoms are complex mixtures of pharmacologically active proteins and peptides which belong to a small number of superfamilies. Global cataloguing of the venom transcriptome facilitates the identification of new families of toxins as well as helps in understanding the evolution of venom proteomes.
RESULTS: We have constructed a cDNA library of the venom gland of a threatened rattlesnake (a pitviper), Sistrurus catenatus edwardsii (Desert Massasauga), and sequenced 576 ESTs. Our results demonstrate a high abundance of serine proteinase and metalloproteinase transcripts, indicating that the disruption of hemostasis is a principle mechanism of action of the venom. In addition …