Open Access. Powered by Scholars. Published by Universities.®
- Discipline
Articles 1 - 2 of 2
Full-Text Articles in Life Sciences
Perturbations In Lineage Specification Of Granulosa And Theca Cells May Alter Corpus Luteum Formation And Function, Mohamed A. Abedel-Majed, Sarah M. Romereim, John S. Davis, Andrea S. Cupp
Perturbations In Lineage Specification Of Granulosa And Theca Cells May Alter Corpus Luteum Formation And Function, Mohamed A. Abedel-Majed, Sarah M. Romereim, John S. Davis, Andrea S. Cupp
Department of Animal Science: Faculty Publications
Anovulation is a major cause of infertility, and it is the major leading reproductive disorder in mammalian females. Without ovulation, an oocyte is not released from the ovarian follicle to be fertilized and a corpus luteum is not formed. The corpus luteum formed from the luteinized somatic follicular cells following ovulation, vasculature cells, and immune cells is critical for progesterone production and maintenance of pregnancy. Follicular theca cells differentiate into small luteal cells (SLCs) that produce progesterone in response to luteinizing hormone (LH), and granulosa cells luteinize to become large luteal cells (LLCs) that have a high rate of basal …
Intramuscular Collagen And Serum Hydroxyproline As Related To Implanted Testosterone, Dihydrotestosterone And Estradiol-17Β In Growing Wethers, L. F. Miller, M. D. Judge, B. D. Schanbacher
Intramuscular Collagen And Serum Hydroxyproline As Related To Implanted Testosterone, Dihydrotestosterone And Estradiol-17Β In Growing Wethers, L. F. Miller, M. D. Judge, B. D. Schanbacher
United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications
Relationships of implanted testosterone, dihydrotestosterone and estradiol-17β to collagen degradation and intramuscular collagen concentration and stability were determined. Intramuscular collagen content, solubility and shrinkage temperature and serum hydroxyproline were analyzed in groups of six rams, wethers, and wethers implanted with various levels of testosterone or dihydrotestosterone (Exp. 1) and groups of 10 rams, wethers and wethers implanted with estradiol-17β, dihydrotestosterone or a combination of these two steroids (Exp. 2). Intramuscular collagen content in both experiments was higher (P < .05) in muscles of rams than in muscles of wethers. Administration of the highest level of testosterone to wethers raised (P < .05) total and insoluble intramuscular collagen to concentrations noted in rams. Administration of the testosterone metabolite, dihydrotestosterone, to wethers had no effect on intramuscular collagen. Administration of estradiol-17β to wethers tended to raise concentrations of intramuscular collagen so that they were no longer lower (P < .05) than those in rams. Collagen stability as measured by solubility and thermal shrinkage temperature did not differ among rams, wethers or implanted wethers (P > .05). Increases in collagen accretion due to hormone administration were observed to be the result of increases in the insoluble portion of …