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Full-Text Articles in Life Sciences
Double-Stranded Rna Technology To Control Insect Pests: Current Status And Challenges, Olivier Christiaens, Steve Whyard, Ana M. Vélez, Guy Smagghe
Double-Stranded Rna Technology To Control Insect Pests: Current Status And Challenges, Olivier Christiaens, Steve Whyard, Ana M. Vélez, Guy Smagghe
Department of Entomology: Faculty Publications
Exploiting the RNA interference (RNAi) gene mechanism to silence essential genes in pest insects, leading to toxic effects, has surfaced as a promising new control strategy in the past decade. While the first commercial RNAi-based products are currently coming to market, the application against a wide range of insect species is still hindered by a number of challenges. In this review, we discuss the current status of these RNAi- based products and the different delivery strategies by which insects can be targeted by the RNAi-triggering double-stranded RNA (dsRNA) molecules. Furthermore, this review also addresses a number of physiological and cellular …
Sublethal Endpoints In Non-Target Organism Testing For Insect-Active Ge Crops, Andrew Roberts, Chad J. Boeckman, Marina Mühl, Jörg Romeis, John L. Teem, Fernando H. Valicente, Judith K. Brown, Steven L. Levine, Richard L. Melnick, Thais B. Rodrigues, Ana M. Vélez, Xuguo Zhou, Richard L. Hellmich, Martin G. Edwards
Sublethal Endpoints In Non-Target Organism Testing For Insect-Active Ge Crops, Andrew Roberts, Chad J. Boeckman, Marina Mühl, Jörg Romeis, John L. Teem, Fernando H. Valicente, Judith K. Brown, Steven L. Levine, Richard L. Melnick, Thais B. Rodrigues, Ana M. Vélez, Xuguo Zhou, Richard L. Hellmich, Martin G. Edwards
Department of Entomology: Faculty Publications
Historically, genetically engineered (GE) plants that have incorporated genes conferring insect protection have primarily used Cry proteins derived from Bacillus thuringiensis (Bt) to achieve their insecticidal phenotype. As a result, regulators have developed a level of familiarity and confidence in reviewing plants incorporating these insecticidal proteins. However, new technologies have been developed that produce GE plants that incorporate pest protection by triggering an RNA interference (RNAi) response or proteins other than Bt Cry proteins. These technologies have new modes of action. Although the overall assessment paradigm for GE plants is robust, there are ongoing discussions about the appropriate tests and …