Life Sciences Commons^™

Regeneration - The Road Not Taken, Raymond E. Sicard

Journal of the Minnesota Academy of Science

Regeneration and repair are mutually-exclusive, adaptive responses to injury. The events associated with each process are well characterized. However, cellular and molecular mechanisms for their regulation are only now beginning to be defined. Moreover, full appreciation for factors that predispose to these contrasting pathways is not yet available. This article presents a perspective on regeneration and repair that suggests specific relationships between these modes of responding to injury. Injury provokes a coordinated pattern of response to tissue damage. At the wound site, local events determine whether tissue restoration or replacement occurs. Interplay among parenchymal and stromal cells at the site …

Regenerative Biology: New Tissues For Old, David L. Stocum

Journal of the Minnesota Academy of Science

Throughout the human life cycle, tissues are regenerated either continuously to maintain tissue integrity in the face of normal cell turnover or in response to acute or chronic damage due to trauma or disease states. Blood, epithelia of skin and tubular organs, hair and nails, and bone marrow are examples of human tissues which regenerate continuously as well as in response to damage. Bone, muscle, adrenal cortex and kidney epithelium also regenerate in response to damage, and bone is continually remodeled in response to stress vectors.

The response of many other vital tissues to damage, however, is not regeneration but …

Wound Repair, Raymond E. Sicard, Jeffry D. Shearer, Michael D. Caldwell

Journal of the Minnesota Academy of Science

Following injury, a series of events is initiated that includes global and local reactions. Global reactions, such as inflammatory and immunological responses as well as adjustments in neural and endocrine status, are directed at marshaling the organism's resources for dealing with changes in its integrity and the potential threat of infection or other complications. Injury entails cell and tissue damage and often a physical breach in the barrier against the outside world (e.g., skin). Local reactions are exemplified by immediate hemostatic (e.g., blood clotting) events followed by changes in local cellular composition created by the inflammatory infiltrate and adjustments in …

Perspectives On Liver Regeneration, Janeen H. Trembley, Clifford J. Steer

Journal of the Minnesota Academy of Science

No abstract provided.

Acceleration Of Amphibian Forelimb Regeneration By Polypeptide Growth Factors, Gehan H. Fahmy, Raymond E. Sicard

Journal of the Minnesota Academy of Science

Growth factors are potentially important modulators of epimorphic regeneration. This study examined effects of intraperitoneal administration of selected growth factors on limb regeneration of adult newts, Notophthalmus viridescens. These agents stimulated regeneration, producing overlapping but nonidentical effects. Fibroblast growth factor-2 (FGF-2) and insulin-like growth factor I (IGF-I) stimulated bud emergence (8.3 ± 0.6 and 8.3 ± 0.7 days, respectively, vs 11.4 ± 1.1 days for controls). Progression to the cone stage was enhanced by both FGF-2 and transforming growth factor beta 5 ( TGF-~ 5) ; 14.6 ± 0.5 and 15.4 ± 0.4 days with FGF-2 and TGF-~5 , respectively, …

Tissue Engineering: At The Interface Between Engineering, Biology And Medicine, Brenda Ogle, Priti Gairola, Jodi Balik, Daniel L. Mooradian

Journal of the Minnesota Academy of Science

No abstract provided.