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Full-Text Articles in Life Sciences
Analysis Of The Cody Rnome Reveals Rsad As A Stress-Responsive Riboregulator Of Overflow Metabolism In Staphylococcus Aureus, Yoann Augagneur, Alyssa N. King, Noëlla Germain-Amiot, Mohamed Sassi, John W. Fitzgerald, Gyan S. Sahukhal, Mohamed O. Elasri, Brice Felden, Shaun R. Brinsmade
Analysis Of The Cody Rnome Reveals Rsad As A Stress-Responsive Riboregulator Of Overflow Metabolism In Staphylococcus Aureus, Yoann Augagneur, Alyssa N. King, Noëlla Germain-Amiot, Mohamed Sassi, John W. Fitzgerald, Gyan S. Sahukhal, Mohamed O. Elasri, Brice Felden, Shaun R. Brinsmade
Faculty Publications
In Staphylococcus aureus, the transcription factor CodY modulates the expression of hundreds of genes, including most virulence factors, in response to the availability of key nutrients like GTP and branched‐chain amino acids. Despite numerous studies examining how CodY controls gene expression directly or indirectly, virtually nothing is known about the extent to which CodY exerts its effect through small regulatory RNAs (sRNAs). Herein, we report the first set of sRNAs under the control of CodY. We reveal that staphylococcal sRNA RsaD is overexpressed >20‐fold in a CodY‐deficient strain in three S. aureus clinical isolates and in S. epidermidis. …